(E)-1-benzyldimethylsilyl-3-methyl-5-(tetrahydropyran-2-yloxy)pent-3-en-1-yne

Base Information

Chemical Name:(E)-1-benzyldimethylsilyl-3-methyl-5-(tetrahydropyran-2-yloxy)pent-3-en-1-yne
CAS No.:1096538-11-2
Molecular Formula:C₂₀H₂₈O₂Si
Molecular Weight:328.527
Hs Code.:

Synonyms:(E)-1-benzyldimethylsilyl-3-methyl-5-(tetrahydropyran-2-yloxy)pent-3-en-1-yne

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-1-benzyldimethylsilyl-3-methyl-5-(tetrahydropyran-2-yloxy)pent-3-en-1-yne

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Technology Process of (E)-1-benzyldimethylsilyl-3-methyl-5-(tetrahydropyran-2-yloxy)pent-3-en-1-yne

There total 1 articles about (E)-1-benzyldimethylsilyl-3-methyl-5-(tetrahydropyran-2-yloxy)pent-3-en-1-yne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 41967-81-1,58389-95-0,61568-79-4,134079-53-1
(E)-tetrahydro-2-<(3-methyl-2-penten-4-ynyl)oxy>-2H-pyran

: 1833-31-4
benzyl(chloro)dimethylsilane

: 1096538-11-2
(E)-1-benzyldimethylsilyl-3-methyl-5-(tetrahydropyran-2-yloxy)pent-3-en-1-yne

Guidance literature:: (E)-tetrahydro-2-<(3-methyl-2-penten-4-ynyl)oxy>-2H-pyran; With n-butyllithium; In diethyl ether; at -78 ℃;

benzyl(chloro)dimethylsilane; In diethyl ether; at -78 - 20 ℃;
DOI:10.1021/ol802551a

Reference yield: 76.0%

: 1096538-11-2
(E)-1-benzyldimethylsilyl-3-methyl-5-(tetrahydropyran-2-yloxy)pent-3-en-1-yne

: 1096538-13-4
(1Z,3E)-1-(benzyldimethylsilyl)-3-methyl-5-(tetrahydropyran-2-yloxy)penta-1,3-diene

Guidance literature:: (E)-1-benzyldimethylsilyl-3-methyl-5-(tetrahydropyran-2-yloxy)pent-3-en-1-yne; With Schwartz's reagent; In tetrahydrofuran;

With pentane;
DOI:10.1021/ol802551a

Reference yield:

: 1096538-11-2
(E)-1-benzyldimethylsilyl-3-methyl-5-(tetrahydropyran-2-yloxy)pent-3-en-1-yne

: 1096538-06-5
11-cis-tetrahydropyran-2-yl retinyl ether

Guidance literature:: Multi-step reaction with 2 steps

1.1: Schwartz's reagent / tetrahydrofuran / 4 h / Inert atmosphere

1.2: 0.33 h / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Darkness

2.2: 1 h / 20 °C / Inert atmosphere; Darkness

With Schwartz's reagent; tetrabutyl ammonium fluoride; In tetrahydrofuran; 2.1: Hiyama coupling / 2.2: Hiyama coupling;
DOI:10.1002/chem.201103360