3'-benzyloxymethyl-1'-thioxo-2',3',6',7'-tetrahydro-1'H-spiro[[1,3]dioxane-2,5'-pyrrolo[1,2-c]pyrimidine]-4'-carboxylic acid methyl ester

Base Information

• Chemical Name: 3'-benzyloxymethyl-1'-thioxo-2',3',6',7'-tetrahydro-1'H-spiro[[1,3]dioxane-2,5'-pyrrolo[1,2-c]pyrimidine]-4'-carboxylic acid methyl ester
• CAS No.: 62987-20-6
• Molecular Formula: C₂₀H₂₄N₂O₅S
• Molecular Weight: 404.487
• Mol file: 62987-20-6.mol

Synonyms:3'-benzyloxymethyl-1'-thioxo-2',3',6',7'-tetrahydro-1'H-spiro[[1,3]dioxane-2,5'-pyrrolo[1,2-c]pyrimidine]-4'-carboxylic acid methyl ester

Chemical Property of 3'-benzyloxymethyl-1'-thioxo-2',3',6',7'-tetrahydro-1'H-spiro[[1,3]dioxane-2,5'-pyrrolo[1,2-c]pyrimidine]-4'-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-benzyloxymethyl-1'-thioxo-2',3',6',7'-tetrahydro-1'H-spiro[[1,3]dioxane-2,5'-pyrrolo[1,2-c]pyrimidine]-4'-carboxylic acid methyl ester

There total 3 articles about 3'-benzyloxymethyl-1'-thioxo-2',3',6',7'-tetrahydro-1'H-spiro[[1,3]dioxane-2,5'-pyrrolo[1,2-c]pyrimidine]-4'-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6,10-dioxa-2-aza-spiro[4.5]decan-1-one (62987-17-1) → 3'-benzyloxymethyl-1'-thioxo-2',3',6',7'-tetrahydro-1'H-spiro[[1,3]dioxane-2,5'-pyrrolo[1,2-c]pyrimidine]-4'-carboxylic acid methyl ester (62987-20-6)

Guidance literature:

Multi-step reaction with 3 steps

1: P₂S₅ / benzene

2: (i) NaHCO₃, CH₂Cl₂, (ii) KOH, MeOH

3: benzene

With tetraphosphorus decasulfide; In benzene;

DOI:10.1021/ja00450a079

Reference yield:

6,10-dioxa-2-aza-spiro[4.5]decane-1-thione (62987-18-2) → 3'-benzyloxymethyl-1'-thioxo-2',3',6',7'-tetrahydro-1'H-spiro[[1,3]dioxane-2,5'-pyrrolo[1,2-c]pyrimidine]-4'-carboxylic acid methyl ester (62987-20-6)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) NaHCO₃, CH₂Cl₂, (ii) KOH, MeOH

2: benzene

In benzene;

DOI:10.1021/ja00450a079

Reference yield:

silicon tetraisothiocyanate (6544-02-1) + benzyloxyacetoaldehyde (60656-87-3) + (6,10-dioxa-2-aza-spiro[4.5]dec-1-ylidene)-acetic acid methyl ester (62987-19-3) → 3'-benzyloxymethyl-1'-thioxo-2',3',6',7'-tetrahydro-1'H-spiro[[1,3]dioxane-2,5'-pyrrolo[1,2-c]pyrimidine]-4'-carboxylic acid methyl ester (62987-20-6)

Guidance literature:

In benzene;

DOI:10.1021/ja00450a079

upstream raw materials:

silicon tetraisothiocyanate

benzyloxyacetoaldehyde

(6,10-dioxa-2-aza-spiro[4.5]dec-1-ylidene)-acetic acid methyl ester

6,10-dioxa-2-aza-spiro[4.5]decan-1-one

Downstream raw materials:

4'c-benzyloxymethyl-6'-thioxo-(3'ar,10'atN¹)-hexahydro-spiro[[1,3]dithiane-2,10'-pyrrolo[1,2-c]purin]-2'-one

4't-benzyloxymethyl-6'-thioxo-(3'ar,10'atN¹)-hexahydro-spiro[[1,3]dithiane-2,10'-pyrrolo[1,2-c]purin]-2'-one

4'c-benzyloxymethyl-(3'ar,10'atN^1')-3'a,4',8',9'-tetrahydro-1'(3')H-spiro[[1,3]dithiane-2,10'-pyrrolo[1,2-c]purine]-2',6'-diamine

(3'-benzyloxymethyl-1'-thioxo-2',3',6',7'-tetrahydro-1'H-spiro[[1,3]dithiane-2,5'-pyrrolo[1,2-c]pyrimidin]-4'-yl)-urea