4-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)phenol hydrochloride

Base Information

Chemical Name:4-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)phenol hydrochloride
CAS No.:1055305-94-6
Molecular Formula:C₁₇H₁₅F₂N₃O₃S*ClH
Molecular Weight:415.848
Hs Code.:

Synonyms:4-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)phenol hydrochloride

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Chemical Property of 4-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)phenol hydrochloride

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Technology Process of 4-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)phenol hydrochloride

There total 13 articles about 4-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)phenol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1055307-47-5
tert-butyl ({4-fluoro-5-(2-fluoropyridin-3-yl)-1-[(4-hydroxyphenyl)sulfonyl]-1H-pyrrol-3-yl}methyl)methylcarbamate

: 1055305-94-6
4-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)phenol hydrochloride

Guidance literature:: With hydrogenchloride; ethanol; In ethyl acetate; at 40 ℃; for 0.5h;

Reference yield:

: 1055306-64-3
tert-butyl 3,3-difluoro-4-methylidene-2-oxopyrrolidine-1-carboxylate

: 1055305-94-6
4-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)phenol hydrochloride

Guidance literature:: Multi-step reaction with 10 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2.75 h / -78 °C

1.2: 3 h / -78 °C

2.1: hydrogenchloride; water; acetic acid / 1 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 18 h / 0 - 60 °C

3.2: 1 h / 0 °C

4.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

4.2: 0.17 h / 0 °C

4.3: 0.25 h / 0 °C

5.1: carbonochloridic acid 1-chloro-ethyl ester / tetrahydrofuran / 0.25 h / 0 °C

5.2: 16 h / 65 °C

5.3: 0.17 h / 20 °C

6.1: tetrahydrofuran / 0.08 h / 20 °C

7.1: sodium hydroxide; water; isopropyl alcohol / tetrahydrofuran / 18 h / 0 - 20 °C

8.1: sodium hydride / tetrahydrofuran / 0.17 h / 20 °C

8.2: 0.5 h

9.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1 h

10.1: hydrogenchloride; ethanol / ethyl acetate / 0.5 h / 40 °C

With hydrogenchloride; sodium hydroxide; n-butyllithium; ethanol; carbonochloridic acid 1-chloro-ethyl ester; water; hydrogen; sodium hydride; acetic acid; diisopropylamine; isopropyl alcohol; palladium 10% on activated carbon; In tetrahydrofuran; hexane; ethyl acetate;

Reference yield:

: 3-(4,4-difluoro-3-methylidene-3,4-dihydro-2H-pyrrol-5-yl)-2-fluoropyridine

: 1055305-94-6
4-({3-fluoro-2-(2-fluoropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)phenol hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / tetrahydrofuran / 18 h / 0 - 60 °C

1.2: 1 h / 0 °C

2.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

2.2: 0.17 h / 0 °C

2.3: 0.25 h / 0 °C

3.1: carbonochloridic acid 1-chloro-ethyl ester / tetrahydrofuran / 0.25 h / 0 °C

3.2: 16 h / 65 °C

3.3: 0.17 h / 20 °C

4.1: tetrahydrofuran / 0.08 h / 20 °C

5.1: sodium hydroxide; water; isopropyl alcohol / tetrahydrofuran / 18 h / 0 - 20 °C

6.1: sodium hydride / tetrahydrofuran / 0.17 h / 20 °C

6.2: 0.5 h

7.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1 h

8.1: hydrogenchloride; ethanol / ethyl acetate / 0.5 h / 40 °C

With hydrogenchloride; sodium hydroxide; ethanol; carbonochloridic acid 1-chloro-ethyl ester; water; hydrogen; sodium hydride; isopropyl alcohol; palladium 10% on activated carbon; In tetrahydrofuran; ethyl acetate;