1-methyl-4-(S)-Cbz-aminopyrazolidine trifluoroacetate

Base Information

Chemical Name:1-methyl-4-(S)-Cbz-aminopyrazolidine trifluoroacetate
CAS No.:128203-55-4
Molecular Formula:C₂HF₃O₂*C₁₂H₁₇N₃O₂
Molecular Weight:349.31
Hs Code.:

Synonyms:1-methyl-4-(S)-Cbz-aminopyrazolidine trifluoroacetate

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Chemical Property of 1-methyl-4-(S)-Cbz-aminopyrazolidine trifluoroacetate

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Technology Process of 1-methyl-4-(S)-Cbz-aminopyrazolidine trifluoroacetate

There total 6 articles about 1-methyl-4-(S)-Cbz-aminopyrazolidine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 128203-54-3
1-t-BOC-2-methyl-4-(R)-Cbz-amino-pyrazolidine

: 76-05-1
trifluoroacetic acid

: 128203-55-4
1-methyl-4-(S)-Cbz-aminopyrazolidine trifluoroacetate

Guidance literature:: In dichloromethane; 1.) 0 deg C, 10 min, 2.) room temperature, 3.5 h;

Reference yield:

: 26054-60-4
((S)-2-Oxo-oxetan-3-yl)-carbamic acid benzyl ester

: 128203-55-4
1-methyl-4-(S)-Cbz-aminopyrazolidine trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / CH₂Cl₂ / 1.25 h / 0 °C

2: 84 percent / diisopropyl azodicarboxylate (DIAD), triphenylphosphine / tetrahydrofuran / 0.58 h / Ambient temperature

3: 62 percent / pyridine / CH₂Cl₂ / 1.) reflux, 6 h, 2.) room temperature, 65 h

4: 90 percent / sodium borohydride (NaBH₄) / ethanol / 1.) 0 deg C, 2 h, 2.) room temperature, 16 h

5: 76 percent / tributylphosphine, diisopropyl azodicarboxylate (DIAD) / tetrahydrofuran / 2 h / Ambient temperature

6: 97 percent / CH₂Cl₂ / 1.) 0 deg C, 10 min, 2.) room temperature, 3.5 h

With pyridine; sodium tetrahydroborate; tributylphosphine; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 128203-51-0
2-methyl-4-(S)-Cbz-aminopyrazolidin-3-one

: 128203-55-4
1-methyl-4-(S)-Cbz-aminopyrazolidine trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: 62 percent / pyridine / CH₂Cl₂ / 1.) reflux, 6 h, 2.) room temperature, 65 h

2: 90 percent / sodium borohydride (NaBH₄) / ethanol / 1.) 0 deg C, 2 h, 2.) room temperature, 16 h

3: 76 percent / tributylphosphine, diisopropyl azodicarboxylate (DIAD) / tetrahydrofuran / 2 h / Ambient temperature

4: 97 percent / CH₂Cl₂ / 1.) 0 deg C, 10 min, 2.) room temperature, 3.5 h

With pyridine; sodium tetrahydroborate; tributylphosphine; di-isopropyl azodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane;