(3R,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-6-methyl-3-<<(phenylmethoxy)carbonyl>amino>heptanoic acid

Base Information

Chemical Name:(3R,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-6-methyl-3-<<(phenylmethoxy)carbonyl>amino>heptanoic acid
CAS No.:104021-85-4
Molecular Formula:C₂₁H₃₂N₂O₆
Molecular Weight:408.495
Hs Code.:

Synonyms:(3R,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-6-methyl-3-<<(phenylmethoxy)carbonyl>amino>heptanoic acid

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Chemical Property of (3R,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-6-methyl-3-<<(phenylmethoxy)carbonyl>amino>heptanoic acid

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Technology Process of (3R,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-6-methyl-3-<<(phenylmethoxy)carbonyl>amino>heptanoic acid

There total 10 articles about (3R,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-6-methyl-3-<<(phenylmethoxy)carbonyl>amino>heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58521-49-6
(3S,4S)-4-(tert-butoxycarbonylamino)-3-hydroxy-6-methylheptanoic acid

: 104021-85-4
(3R,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-6-methyl-3-<<(phenylmethoxy)carbonyl>amino>heptanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 67 percent / diethyl phosphorocyanidate, triethylamine / CH₂Cl₂ / 1 h / 0 °C

2: pyridine / 2 h / 0 °C

3: potassium carbonate / acetone / 72 h / Heating

4: 90 percent / sodium, liq. ammonia / tetrahydrofuran / 0.5 h / -33 °C

5: 1 N potassium hydroxide / methanol / 3 h / Ambient temperature

6: potassium carbonate / dimethylformamide / 1.) 0 deg C, 4 h, 2.) RT, 48 h

With pyridine; potassium hydroxide; diethyl cyanophosphonate; ammonia; sodium; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00250a046

Reference yield:

: 118585-36-7
Methanesulfonic acid (1S,2S)-2-tert-butoxycarbonylamino-1-(methoxycarbamoyl-methyl)-4-methyl-pentyl ester

: 104021-85-4
(3R,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-6-methyl-3-<<(phenylmethoxy)carbonyl>amino>heptanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 72 h / Heating

2: 90 percent / sodium, liq. ammonia / tetrahydrofuran / 0.5 h / -33 °C

3: 1 N potassium hydroxide / methanol / 3 h / Ambient temperature

4: potassium carbonate / dimethylformamide / 1.) 0 deg C, 4 h, 2.) RT, 48 h

With potassium hydroxide; ammonia; sodium; potassium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00250a046

Reference yield:

: 115017-05-5
(1S,2R)-<1-(4-oxo-2-azetidinyl)-3-methylbutyl>carbamic acid 1,1-dimethylethyl ester

: 104021-85-4
(3R,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-6-methyl-3-<<(phenylmethoxy)carbonyl>amino>heptanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1 N potassium hydroxide / methanol / 3 h / Ambient temperature

2: potassium carbonate / dimethylformamide / 1.) 0 deg C, 4 h, 2.) RT, 48 h

With potassium hydroxide; potassium carbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00250a046