(2S,3R)-3-(3,5-dibenzyloxyphenoxy)-3-(3,5-dibenzyloxyphenyl)-propane-1,2-diol

Base Information

Chemical Name:(2S,3R)-3-(3,5-dibenzyloxyphenoxy)-3-(3,5-dibenzyloxyphenyl)-propane-1,2-diol
CAS No.:1607010-81-0
Molecular Formula:C₄₃H₄₀O₇
Molecular Weight:668.786
Hs Code.:

Synonyms:(2S,3R)-3-(3,5-dibenzyloxyphenoxy)-3-(3,5-dibenzyloxyphenyl)-propane-1,2-diol

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Chemical Property of (2S,3R)-3-(3,5-dibenzyloxyphenoxy)-3-(3,5-dibenzyloxyphenyl)-propane-1,2-diol

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Technology Process of (2S,3R)-3-(3,5-dibenzyloxyphenoxy)-3-(3,5-dibenzyloxyphenyl)-propane-1,2-diol

There total 2 articles about (2S,3R)-3-(3,5-dibenzyloxyphenoxy)-3-(3,5-dibenzyloxyphenyl)-propane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 63604-98-8
1,3-dibenzylphloroglucinol

: 1607010-78-5
(2S,3S)-3-(3,5-bis(benzyloxy)-phenyl)-oxiran-2-yl methanol

: 1607010-81-0
(2S,3R)-3-(3,5-dibenzyloxyphenoxy)-3-(3,5-dibenzyloxyphenyl)-propane-1,2-diol

Guidance literature:: 1,3-dibenzylphloroglucinol; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1.5h;

(2S,3S)-3-(3,5-bis(benzyloxy)-phenyl)-oxiran-2-yl methanol; In tetrahydrofuran; water; for 14h; Reflux;
DOI:10.1016/j.tet.2014.03.052

Reference yield:

: 3,5-dibenzyloxycinnamyl alcohol

: 1607010-81-0
(2S,3R)-3-(3,5-dibenzyloxyphenoxy)-3-(3,5-dibenzyloxyphenyl)-propane-1,2-diol

Guidance literature:: Multi-step reaction with 2 steps

1.1: diethyl L-tartrate; titanium(IV) isopropylate; tert.-butylhydroperoxide / dichloromethane / 3 h / -20 °C / Molecular sieve

2.1: sodium hydride / tetrahydrofuran / 1.5 h / 20 °C

2.2: 14 h / Reflux

With titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl L-tartrate; sodium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2014.03.052

Reference yield: 46.0%

: 1607010-81-0
(2S,3R)-3-(3,5-dibenzyloxyphenoxy)-3-(3,5-dibenzyloxyphenyl)-propane-1,2-diol

: 1607010-84-3
(S)-2-(R)-(3,5-bis(benzyloxy)-phenyl)-(3,5-dibenzyloxyphenoxy)-methyl oxirane

Guidance literature:: (2S,3R)-3-(3,5-dibenzyloxyphenoxy)-3-(3,5-dibenzyloxyphenyl)-propane-1,2-diol; With dmap; triethylamine; p-toluenesulfonyl chloride; In dichloromethane; at 20 ℃; for 48h;

With potassium carbonate; In methanol; at 20 ℃; for 2h;
DOI:10.1016/j.tet.2014.03.052