7-methyl-6-phenylindolo[1,2-a]quinoline

Base Information

• Chemical Name: 7-methyl-6-phenylindolo[1,2-a]quinoline
• CAS No.: 1404454-05-2
• Molecular Formula: C₂₃H₁₇N
• Molecular Weight: 307.395
• Mol file: 1404454-05-2.mol

Synonyms:7-methyl-6-phenylindolo[1,2-a]quinoline

Chemical Property of 7-methyl-6-phenylindolo[1,2-a]quinoline

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 7-methyl-6-phenylindolo[1,2-a]quinoline

There total 6 articles about 7-methyl-6-phenylindolo[1,2-a]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-methyl-1-(2-(phenylethynyl)phenyl)-1H-indole → 7-methyl-6-phenylindolo[1,2-a]quinoline (1404454-05-2)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); In 1,2-dichloro-ethane; at 90 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.0c01519

Reference yield: 76.0%

1-(2-bromo-phenyl)-3-methyl-1H-indole (1192740-24-1) + phenylacetylene (536-74-3) → 7-methyl-6-phenylindolo[1,2-a]quinoline (1404454-05-2)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium acetate; lithium chloride; In dimethyl amine; at 120 ℃; for 28h; Reagent/catalyst; Solvent; Temperature; regioselective reaction; Inert atmosphere;

DOI:10.1021/jo302112a

Reference yield: 64.0%

1-(2-bromo-phenyl)-3-methyl-1H-indole (1192740-24-1) + phenylacetylene (536-74-3) → 3-methyl-1-(2-(phenylethynyl)phenyl)-1H-indole (1311312-53-4) + 7-methyl-6-phenylindolo[1,2-a]quinoline (1404454-05-2)

Guidance literature:

With sodium acetate; palladium diacetate; lithium chloride; In N,N-dimethyl-formamide; at 120 ℃; for 28h; Reagent/catalyst; Solvent; Temperature; regioselective reaction; Inert atmosphere;

DOI:10.1021/jo302112a

upstream raw materials:

1-(2-bromo-phenyl)-3-methyl-1H-indole

phenylacetylene

3-Methylindole

1-Bromo-2-iodobenzene