N-[(5-{(1R)-1-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-2-hydroxyethyl}thiophen-2-yl)methyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

Base Information

Chemical Name:N-[(5-{(1R)-1-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-2-hydroxyethyl}thiophen-2-yl)methyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide
CAS No.:1431877-39-2
Molecular Formula:C₃₅H₃₈N₄O₆S₃
Molecular Weight:706.908
Hs Code.:

N-[(5-{(1R)-1-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-2-hydroxyethyl}thiophen-2-yl)methyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

Synonyms:N-[(5-{(1R)-1-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-2-hydroxyethyl}thiophen-2-yl)methyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

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Chemical Property of N-[(5-{(1R)-1-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-2-hydroxyethyl}thiophen-2-yl)methyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

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Technology Process of N-[(5-{(1R)-1-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-2-hydroxyethyl}thiophen-2-yl)methyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

There total 11 articles about N-[(5-{(1R)-1-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-2-hydroxyethyl}thiophen-2-yl)methyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431877-52-9
N-{(1R)-1-[5-(aminomethyl)thiophen-2-yl]-2-hydroxyethyl}-N-(2-methylpropyl)-1,3-benzothiazole-6-sulfonamide hydrochloride

: 161869-03-0
(S)-2-((methoxycarbonyl)amino)-3,3-diphenylpropanoic acid

: 1431877-39-2
N-[(5-{(1R)-1-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-2-hydroxyethyl}thiophen-2-yl)methyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 4h;

Reference yield:

: 1431878-07-7
(2R)-2-amino-2-[5-(5,5-dimethyl-1,3-dioxan-2-yl)thiophen-2-yl]ethanol hydrochloride

: 1431877-39-2
N-[(5-{(1R)-1-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-2-hydroxyethyl}thiophen-2-yl)methyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / dichloromethane / 0.25 h / 0 °C

2: 1H-imidazole / N,N-dimethyl-formamide

3: titanium(IV) isopropylate / tetrahydrofuran / 20 °C

4: cyanomethylenetributyl-phosphorane / toluene / 2 h / 100 °C

5: sodium tetrahydroborate / methanol / 4 h / 0 °C

6: hydrogenchloride / 1,4-dioxane; methanol / 5 h

7: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 0 °C

With 1H-imidazole; titanium(IV) isopropylate; hydrogenchloride; sodium tetrahydroborate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; cyanomethylenetributyl-phosphorane; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1431877-51-8
N-[(1R)-1-(5-formylthiophen-2-yl)-2-hydroxyethyl]-1,3-benzothiazole-6-sulfonamide

: 1431877-39-2
N-[(5-{(1R)-1-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-2-hydroxyethyl}thiophen-2-yl)methyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

Guidance literature:: Multi-step reaction with 6 steps

1: 1H-imidazole / N,N-dimethyl-formamide

2: titanium(IV) isopropylate / tetrahydrofuran / 20 °C

3: cyanomethylenetributyl-phosphorane / toluene / 2 h / 100 °C

4: sodium tetrahydroborate / methanol / 4 h / 0 °C

5: hydrogenchloride / 1,4-dioxane; methanol / 5 h

6: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 0 °C

With 1H-imidazole; titanium(IV) isopropylate; hydrogenchloride; sodium tetrahydroborate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; cyanomethylenetributyl-phosphorane; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene;