(4S,5S)-N-methyl-4-hydroxy-5-<<(tert-butyloxy)carbonyl>amino>-6-phenylhex-1-ene-2-carboxamide

Base Information

Chemical Name:(4S,5S)-N-methyl-4-hydroxy-5-<<(tert-butyloxy)carbonyl>amino>-6-phenylhex-1-ene-2-carboxamide
CAS No.:104293-38-1
Molecular Formula:C₁₉H₂₈N₂O₄
Molecular Weight:348.442
Hs Code.:

Synonyms:(4S,5S)-N-methyl-4-hydroxy-5-<<(tert-butyloxy)carbonyl>amino>-6-phenylhex-1-ene-2-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,5S)-N-methyl-4-hydroxy-5-<<(tert-butyloxy)carbonyl>amino>-6-phenylhex-1-ene-2-carboxamide

Chemical Property:

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Technology Process of (4S,5S)-N-methyl-4-hydroxy-5-<<(tert-butyloxy)carbonyl>amino>-6-phenylhex-1-ene-2-carboxamide

There total 1 articles about (4S,5S)-N-methyl-4-hydroxy-5-<<(tert-butyloxy)carbonyl>amino>-6-phenylhex-1-ene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 66605-57-0
(S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol

: 104293-38-1
(4S,5S)-N-methyl-4-hydroxy-5-<<(tert-butyloxy)carbonyl>amino>-6-phenylhex-1-ene-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / sulfur trioxide, pyridine, triethylamine, DMSO / CH₂Cl₂ / 1 h / 0 °C

2: 1.) chlorotitanium triisopropoxide / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, a.) -78 deg C, 15 min, b.) 0 deg C, 30 min

With pyridine; triisopropoxytitanium(IV) chloride; sulfur trioxide; dimethyl sulfoxide; triethylamine; In dichloromethane;
DOI:10.1021/jo00371a001

Reference yield:

: 104293-38-1
(4S,5S)-N-methyl-4-hydroxy-5-<<(tert-butyloxy)carbonyl>amino>-6-phenylhex-1-ene-2-carboxamide

: ((1S,2S)-1-Benzyl-2-hydroxy-4-methylcarbamoyl-pentyl)-carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 24h;
DOI:10.1021/jo00371a001

Reference yield:

: 104293-38-1
(4S,5S)-N-methyl-4-hydroxy-5-<<(tert-butyloxy)carbonyl>amino>-6-phenylhex-1-ene-2-carboxamide

: 104293-55-2
(3R,5S,1'S)-5-<1-<<(tert-butyloxy)carbonyl>amino>-2-phenylethyl>-3-methyldihydrofuran-2(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 100 mg / H₂ / 10percent Pd/C / ethyl acetate / 24 h

2: xylene / 14 h / Heating

With hydrogen; palladium on activated charcoal; In ethyl acetate; xylene;
DOI:10.1021/jo00371a001