(4-ethoxyphenyl)hydrazine hydrochloride

Base Information

• Chemical Name: (4-ethoxyphenyl)hydrazine hydrochloride
• CAS No.: 76014-10-3
• Molecular Formula: C8H12 N2 O . Cl H
• Molecular Weight: 188.657
• Hs Code.: 2928000090
• Mol file: 76014-10-3.mol

Synonyms:Hydrazine,(4-ethoxyphenyl)-, monohydrochloride (9CI); Hydrazine, (p-ethoxyphenyl)-,hydrochloride (6CI,7CI)

Chemical Property of (4-ethoxyphenyl)hydrazine hydrochloride

Chemical Property:

• PSA: 47.28000
• LogP: 2.94620

Purity/Quality:

98%Min ^*data from raw suppliers

(4-Ethoxyphenyl)hydrazine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (4-Ethoxyphenyl)hydrazine Hydrochloride is used in the preparation of N-(piperazin-1-yl)alkyl-1H-dibenzo[a,c]carbazole derivatives of dehydroabietic acid as potential MEK inhibitors.

Technology Process of (4-ethoxyphenyl)hydrazine hydrochloride

There total 2 articles about (4-ethoxyphenyl)hydrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-(4-ethoxyphenyl)-sydnone (3815-82-5) → (4-ethoxyphenyl)hydrazine hydrochloride (76014-10-3)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 60 ℃; for 0.25h;

DOI:10.1002/jccs.200000027

Reference yield:

4-Ethoxyaniline (156-43-4) → (4-ethoxyphenyl)hydrazine hydrochloride (76014-10-3)

Guidance literature:

4-Ethoxyaniline; With hydrogenchloride; sodium nitrite; In water; at 0 - 5 ℃;

With hydrogenchloride; tin(ll) chloride; In water; at 0 - 20 ℃;

DOI:10.1016/j.ejmech.2010.07.038

Reference yield: 91.0%

4,5,6,7-tetrahydro-α,4-dioxobenzothiophene-5-acetic acid ethyl ester (14779-31-8) + (4-ethoxyphenyl)hydrazine hydrochloride (76014-10-3) → ethyl 1-(4-ethoxyphenyl)-4,5-dihydro-1H-thieno[2,3-g]indazole-3-carboxylate

Guidance literature:

In ethanol; at 65 ℃; for 3h; Inert atmosphere;

upstream raw materials:

3-(4-ethoxyphenyl)-sydnone

4-Ethoxyaniline

Downstream raw materials:

1-(4-ethoxyphenyl)-4-phenylcarbazide

1-(4-ethoxyphenyl)-4-(4-methylphenyl)carbazide

N'-(4-Ethoxyphenyl)-4,4-ethylenedioxycyclohexanecarbohydrazide

Refernces

• 1、 Gu, Wen,Wang, Shifa. "Synthesis and antimicrobial activities of novel 1H-dibenzo[a,c]carbazoles from dehydroabietic acid". experimental part. p. 4692 - 4696. Retrieved 2010/10/03.