1-(tert-butoxycarbonyl)-2-isopropyl-4-[(2-pyrrolidin-1-ylazo)phenyl]-5-(3-hydroxypropyl)pyrrole

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Chemical Name:1-(tert-butoxycarbonyl)-2-isopropyl-4-[(2-pyrrolidin-1-ylazo)phenyl]-5-(3-hydroxypropyl)pyrrole
CAS No.:869670-78-0
Molecular Formula:C₂₅H₃₆N₄O₃
Molecular Weight:440.586
Hs Code.:

Synonyms:1-(tert-butoxycarbonyl)-2-isopropyl-4-[(2-pyrrolidin-1-ylazo)phenyl]-5-(3-hydroxypropyl)pyrrole

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Chemical Property of 1-(tert-butoxycarbonyl)-2-isopropyl-4-[(2-pyrrolidin-1-ylazo)phenyl]-5-(3-hydroxypropyl)pyrrole

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Technology Process of 1-(tert-butoxycarbonyl)-2-isopropyl-4-[(2-pyrrolidin-1-ylazo)phenyl]-5-(3-hydroxypropyl)pyrrole

There total 8 articles about 1-(tert-butoxycarbonyl)-2-isopropyl-4-[(2-pyrrolidin-1-ylazo)phenyl]-5-(3-hydroxypropyl)pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 869670-71-3
N-(tert-Butoxycarbonyl)-2-isopropyl-4-bromo-5-(3-hydroxypropyl)pyrrole

: 869670-79-1
(2-triazenyl)phenylboronic acid

: 869670-83-7
2-(3-Hydroxy-propyl)-5-isopropyl-pyrrole-1-carboxylic acid tert-butyl ester

: 869670-78-0
1-(tert-butoxycarbonyl)-2-isopropyl-4-[(2-pyrrolidin-1-ylazo)phenyl]-5-(3-hydroxypropyl)pyrrole

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 80 ℃;

Reference yield:

: 869670-67-7
(2Z)-2-bromo-4-[N-(tert-butoxycarbonyl)amino]-5-methyl-hex-2-enal

: 869670-78-0
1-(tert-butoxycarbonyl)-2-isopropyl-4-[(2-pyrrolidin-1-ylazo)phenyl]-5-(3-hydroxypropyl)pyrrole

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 1 h / -70 °C

2: Dess-Martin periodane / dichloromethane / 1 h

3: hydrogenchloride / diethyl ether; dichloromethane / 20 °C

4: tetrahydrofuran / 20.5 h / -20 - 20 °C

5: dihydrogen peroxide; sodium carbonate / tetrahydrofuran; ethanol; water / 0.5 h / Heating / reflux

6: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 80 °C

With hydrogenchloride; dihydrogen peroxide; sodium carbonate; potassium carbonate; Dess-Martin periodane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane; water; 6: Suzuki-Miyaura coupling;

Reference yield:

: 869670-69-9
(2Z)-5-methyl-4-(N-tert-butoxycarbonyl)amino-2-bromo-1-allylhexen-1-one

: 869670-78-0
1-(tert-butoxycarbonyl)-2-isopropyl-4-[(2-pyrrolidin-1-ylazo)phenyl]-5-(3-hydroxypropyl)pyrrole

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / diethyl ether; dichloromethane / 20 °C

2: tetrahydrofuran / 20.5 h / -20 - 20 °C

3: dihydrogen peroxide; sodium carbonate / tetrahydrofuran; ethanol; water / 0.5 h / Heating / reflux

4: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 80 °C

With hydrogenchloride; dihydrogen peroxide; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane; water; 4: Suzuki-Miyaura coupling;