(1R,4S,5S,6S)-5-[4-(1,1-Dimethyl-heptyl)-2,6-dimethoxy-phenyl]-4-isopropenyl-1-methyl-7-oxa-bicyclo[4.1.0]heptane

Base Information

Chemical Name:(1R,4S,5S,6S)-5-[4-(1,1-Dimethyl-heptyl)-2,6-dimethoxy-phenyl]-4-isopropenyl-1-methyl-7-oxa-bicyclo[4.1.0]heptane
CAS No.:847949-36-4
Molecular Formula:C₂₇H₄₂O₃
Molecular Weight:414.629
Hs Code.:

Synonyms:(1R,4S,5S,6S)-5-[4-(1,1-Dimethyl-heptyl)-2,6-dimethoxy-phenyl]-4-isopropenyl-1-methyl-7-oxa-bicyclo[4.1.0]heptane

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Chemical Property of (1R,4S,5S,6S)-5-[4-(1,1-Dimethyl-heptyl)-2,6-dimethoxy-phenyl]-4-isopropenyl-1-methyl-7-oxa-bicyclo[4.1.0]heptane

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Technology Process of (1R,4S,5S,6S)-5-[4-(1,1-Dimethyl-heptyl)-2,6-dimethoxy-phenyl]-4-isopropenyl-1-methyl-7-oxa-bicyclo[4.1.0]heptane

There total 1 articles about (1R,4S,5S,6S)-5-[4-(1,1-Dimethyl-heptyl)-2,6-dimethoxy-phenyl]-4-isopropenyl-1-methyl-7-oxa-bicyclo[4.1.0]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 847949-35-3
5-(1,1-Dimethyl-heptyl)-2-((1S,6S)-6-isopropenyl-3-methyl-cyclohex-2-enyl)-1,3-dimethoxy-benzene

: 847949-36-4
(1R,4S,5S,6S)-5-[4-(1,1-Dimethyl-heptyl)-2,6-dimethoxy-phenyl]-4-isopropenyl-1-methyl-7-oxa-bicyclo[4.1.0]heptane

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1039/b416943c

Reference yield: 97.0%

: 847949-36-4
(1R,4S,5S,6S)-5-[4-(1,1-Dimethyl-heptyl)-2,6-dimethoxy-phenyl]-4-isopropenyl-1-methyl-7-oxa-bicyclo[4.1.0]heptane

: (3S,4S)-3-[4-(1',1'-dimethylheptyl)-2,6-dimethoxyphenyl]-2-hydroxy-4-isopropenyl-1-methylenecyclohexane

Guidance literature:: With n-butyllithium; N-cyclohexylisopropylamine; methylmagnesium bromide; In diethyl ether; toluene; at 40 ℃; for 2h;
DOI:10.1039/b416943c

Reference yield:

: 847949-36-4
(1R,4S,5S,6S)-5-[4-(1,1-Dimethyl-heptyl)-2,6-dimethoxy-phenyl]-4-isopropenyl-1-methyl-7-oxa-bicyclo[4.1.0]heptane

: 847949-41-1
{(3S,4S)-3-[4-(1,1-Dimethyl-heptyl)-2,6-dimethoxy-phenyl]-4-isopropenyl-cyclohex-1-enyl}-methanol

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / BuLi; N-cyclohexylisopropylamine; methylmagnesium bromide / toluene; diethyl ether / 2 h / 40 °C

2: 100 percent / pyridine / 18 h / 20 °C

3: 90 percent / TMSBr / CH₂Cl₂ / 4 h / 20 °C

4: 92 percent / 4 Angstroem molecular sieves / 2 h / Heating

5: 94 percent / aq. NaOH / ethanol / 1 h / Heating

With pyridine; sodium hydroxide; n-butyllithium; trimethylsilyl bromide; 4 A molecular sieve; N-cyclohexylisopropylamine; methylmagnesium bromide; In diethyl ether; ethanol; dichloromethane; toluene;
DOI:10.1039/b416943c