(S)-2-PROPYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: (S)-2-PROPYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 888972-67-6
• Molecular Formula: C₁₂H₂₄N₂O₂
• Molecular Weight: 228.335
• Mol file: 888972-67-6.mol

Synonyms:1-N-boc-2-n-propylpiperazine;(S)-1-Boc -2-propyl-piperazine;(S)-1-Boc-2-propyl-piperazine;(R)-1-Boc-2-propyl-piperazine;

Chemical Property of (S)-2-PROPYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Vapor Pressure: 0.000906mmHg at 25°C
• Refractive Index: 1.458
• Boiling Point: 303.9 °C at 760 mmHg
• Flash Point: 137.6 °C
• PSA: 41.57000
• Density: 0.972g/cm³
• LogP: 2.26210
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

(S)-1-Boc-2-Propylpiperazine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-2-PROPYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 3 articles about (S)-2-PROPYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(S)-4-benzyl-2-propyl-piperazine-1-carboxylic acid tert-butyl ester (888972-66-5) → (S)-2-propyl-piperazine-1-carboxylic acid tert-butyl ester (888972-67-6)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 6h; under 2250.23 Torr;

Reference yield:

(S)-1-benzyl-3-propylpiperazine (324749-73-7,928025-41-6) + di-tert-butyl dicarbonate (24424-99-5) → (S)-2-propyl-piperazine-1-carboxylic acid tert-butyl ester (888972-67-6)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

2: hydrogen; palladium on activated charcoal / methanol / 6 h / 20 °C / 2250.23 Torr

With palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;

Reference yield:

→ (S)-2-propyl-piperazine-1-carboxylic acid tert-butyl ester (888972-67-6)

Guidance literature:

upstream raw materials:

(S)-4-benzyl-2-propyl-piperazine-1-carboxylic acid tert-butyl ester

(S)-1-benzyl-3-propylpiperazine

di-tert-butyl dicarbonate

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