Technology Process of 2-((4S,4aS,10bS)-10b-((4-chlorophenyl)sulfonyl)-7,10-difluoro-1,2,4,4a,5,10b-hexahydropyrano[3,4-c]chromene-4-yl)ethyl 4-methanesulfinate
There total 9 articles about 2-((4S,4aS,10bS)-10b-((4-chlorophenyl)sulfonyl)-7,10-difluoro-1,2,4,4a,5,10b-hexahydropyrano[3,4-c]chromene-4-yl)ethyl 4-methanesulfinate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C27H25ClF2O7S2;
With
tetra-(n-butyl)ammonium iodide;
In
tetrahydrofuran;
for 2h;
Reflux;
sodium methansulfinate;
In
tetrahydrofuran;
Reflux;
DOI:10.1021/ml300044f
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1 h / -78 - 20 °C
2.1: boron trifluoride diethyl etherate / dichloromethane / 24 h / Reflux
3.1: oxone / acetone; water / 3 h / 50 °C
4.1: methanesulfonyl chloride; triethylamine / dichloromethane / 1.5 h / 20 °C
4.2: 0.5 h / 20 °C
5.1: ozone; sodium tetrahydroborate; methanol / dichloromethane / -78 - 20 °C / Inert atmosphere
5.2: 1 h / Inert atmosphere
6.1: chiralcel OJ / isopropyl alcohol; hexane / Resolution of racemate
7.1: triethylamine / dichloromethane / 20 °C
8.1: tetra-(n-butyl)ammonium iodide / tetrahydrofuran / 2 h / Reflux
8.2: Reflux
With
methanol; sodium tetrahydroborate; oxone; trimethylsilyl trifluoromethanesulfonate; boron trifluoride diethyl etherate; tetra-(n-butyl)ammonium iodide; ozone; methanesulfonyl chloride; triethylamine;
In
tetrahydrofuran; hexane; dichloromethane; water; isopropyl alcohol; acetone;
DOI:10.1021/ml300044f
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane / 20 °C
2.1: tetra-(n-butyl)ammonium iodide / tetrahydrofuran / 2 h / Reflux
2.2: Reflux
With
tetra-(n-butyl)ammonium iodide; triethylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ml300044f
