C₂₆H₃₃N₃O₅S

Base Information

• Chemical Name: C₂₆H₃₃N₃O₅S
• CAS No.: 1257832-23-7
• Molecular Formula: C₂₆H₃₃N₃O₅S
• Molecular Weight: 499.631
• Mol file: 1257832-23-7.mol

Synonyms:C₂₆H₃₃N₃O₅S

Chemical Property of C₂₆H₃₃N₃O₅S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₃₃N₃O₅S

There total 6 articles about C₂₆H₃₃N₃O₅S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

tert-butyl carbazate (4248-19-5) + N-[4-(8-bromo-6-tert-butyl-5-methoxy-3-quinolyl)phenyl]methanesulfonamide (1257830-36-6) → C26H33N3O5S (1257832-23-7)

Guidance literature:

With sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tert-butyl XPhos; In toluene; at 20 ℃; for 48h; Inert atmosphere; microwave irradiation; sealed tube;

Reference yield:

4-(1,1-dimethylethyl)-3-(methoxy)benzoic acid (79822-46-1) → C26H33N3O5S (1257832-23-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: diphenylphosphoranyl azide; triethylamine / tetrahydrofuran / 23 h / Reflux; Inert atmosphere

2.1: potassium hydroxide; water / ethanol / 15 h / Reflux; Inert atmosphere

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

4.1: bromine; acetic acid / 0.25 h / 20 °C / Inert atmosphere

4.2: 4 h / 100 °C / Inert atmosphere

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / methanol; toluene / 1 h / 120 °C / Inert atmosphere; Sealed tube; Microwave irradiation

6.1: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tert-butyl XPhos; sodium t-butanolate / toluene / 20 °C / Inert atmosphere; Sealed tube

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenylphosphoranyl azide; water; bromine; sodium carbonate; acetic acid; triethylamine; potassium hydroxide; sodium t-butanolate; tert-butyl XPhos; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; toluene; 1.1: |Curtius Rearrangement;

DOI:10.1021/jm401329s

Reference yield:

ethyl N-(4-tert-butyl-3-methoxyphenyl)carbamate (1485748-67-1) → C26H33N3O5S (1257832-23-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium hydroxide; water / ethanol / 15 h / Reflux; Inert atmosphere

2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

3.1: bromine; acetic acid / 0.25 h / 20 °C / Inert atmosphere

3.2: 4 h / 100 °C / Inert atmosphere

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / methanol; toluene / 1 h / 120 °C / Inert atmosphere; Sealed tube; Microwave irradiation

5.1: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tert-butyl XPhos; sodium t-butanolate / toluene / 20 °C / Inert atmosphere; Sealed tube

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; bromine; sodium carbonate; acetic acid; potassium hydroxide; sodium t-butanolate; tert-butyl XPhos; In methanol; ethanol; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm401329s

upstream raw materials:

tert-butyl carbazate

N-[4-(8-bromo-6-tert-butyl-5-methoxy-3-quinolyl)phenyl]methanesulfonamide

4-(1,1-dimethylethyl)-3-(methoxy)benzoic acid

ethyl N-(4-tert-butyl-3-methoxyphenyl)carbamate

Downstream raw materials:

N-[4-(8-amino-6-tert-butyl-5-methoxy-3-quinolyl)phenyl]methanesulfonamide

N-{4-[6-tert-butyl-8-(2,4-dioxo-tetrahydro-pyrimidin-1-yl)-5-methoxy-quinolin-3-yl]-phenyl}-methanesulfonamide