2-hydroxy-6-(2-hydroxypropyl)-4-methoxy-3-methylbenzaldehyde

Base Information

• Chemical Name: 2-hydroxy-6-(2-hydroxypropyl)-4-methoxy-3-methylbenzaldehyde
• CAS No.: 886989-18-0
• Molecular Formula: C₁₂H₁₆O₄
• Molecular Weight: 224.257
• Mol file: 886989-18-0.mol

Synonyms:2-hydroxy-6-(2-hydroxypropyl)-4-methoxy-3-methylbenzaldehyde

Chemical Property of 2-hydroxy-6-(2-hydroxypropyl)-4-methoxy-3-methylbenzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-hydroxy-6-(2-hydroxypropyl)-4-methoxy-3-methylbenzaldehyde

There total 4 articles about 2-hydroxy-6-(2-hydroxypropyl)-4-methoxy-3-methylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.9%

1-(3-hydroxy-5-methoxy-4-methylphenyl)-2-propanol (886989-19-1) + orthoformic acid triethyl ester (122-51-0) → 2-hydroxy-6-(2-hydroxypropyl)-4-methoxy-3-methylbenzaldehyde (886989-18-0) + 1,1'-oxydi(8-hydroxy-6-methoxy-3,7-dimethylisochromane) (886989-22-6)

Guidance literature:

With aluminium trichloride; In toluene; at -53 - -30 ℃;

DOI:10.1016/j.tet.2006.01.079

Reference yield: 15.0%

1-(3-hydroxy-5-methoxy-4-methylphenyl)-2-propanol (886989-19-1) + orthoformic acid triethyl ester (122-51-0) → 1,8-dihydroxy-6-methoxy-3,7-dimethylisochromane (887129-82-0) + 2-hydroxy-6-(2-hydroxypropyl)-4-methoxy-3-methylbenzaldehyde (886989-18-0) + 1,1'-oxydi(8-hydroxy-6-methoxy-3,7-dimethylisochromane) (886989-22-6)

Guidance literature:

With aluminium trichloride; In toluene; at -48 - -30 ℃; Title compound not separated from byproducts;

DOI:10.1016/j.tet.2006.01.079

Reference yield:

1,8-dihydroxy-6-methoxy-3,7-dimethylisochromane (887129-82-0) → 2-hydroxy-6-(2-hydroxypropyl)-4-methoxy-3-methylbenzaldehyde (886989-18-0)

Guidance literature:

In acetone; at 20 ℃;

DOI:10.1016/j.tet.2006.01.079

upstream raw materials:

1,8-dihydroxy-6-methoxy-3,7-dimethylisochromane

1-(3-hydroxy-5-methoxy-4-methylphenyl)-2-propanol

orthoformic acid triethyl ester

1-(3-hydroxy-5-methoxy-4-methylphenyl)-2-propanone

Downstream raw materials:

8-hydroxy-6-methoxy-3,7-dimethylisochromane