2-[4-(1-fluoro-2-{[(methylethyl)sulfonyl]amino}cyclopentyl)phenoxy]ethanenitrile

Base Information

Chemical Name:2-[4-(1-fluoro-2-{[(methylethyl)sulfonyl]amino}cyclopentyl)phenoxy]ethanenitrile
CAS No.:415897-75-5
Molecular Formula:C₁₆H₂₁FN₂O₃S
Molecular Weight:340.419
Hs Code.:

Synonyms:2-[4-(1-fluoro-2-{[(methylethyl)sulfonyl]amino}cyclopentyl)phenoxy]ethanenitrile

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Chemical Property of 2-[4-(1-fluoro-2-{[(methylethyl)sulfonyl]amino}cyclopentyl)phenoxy]ethanenitrile

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Technology Process of 2-[4-(1-fluoro-2-{[(methylethyl)sulfonyl]amino}cyclopentyl)phenoxy]ethanenitrile

There total 3 articles about 2-[4-(1-fluoro-2-{[(methylethyl)sulfonyl]amino}cyclopentyl)phenoxy]ethanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 415898-33-8
2-[4-(1-hydroxy-2-{[(methylethyl)sulfonyl]amino}cyclopentyl)phenoxy]ethanenitrile

: 415897-75-5
2-[4-(1-fluoro-2-{[(methylethyl)sulfonyl]amino}cyclopentyl)phenoxy]ethanenitrile

Guidance literature:: With trans-4,4'-diaminostilbene-2,2'-disulfonic acid; In ethyl acetate;

Reference yield:

: 477875-68-6
trans-{2-Hydroxy-2-[4-(phenylmethoxy)phenyl]cyclopentyl}[(methylethyl)sulfonyl]amine

: 415897-75-5
2-[4-(1-fluoro-2-{[(methylethyl)sulfonyl]amino}cyclopentyl)phenoxy]ethanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: palladium / methanol; ethyl acetate

2: potassium carbonate / ethyl acetate; acetone

3: trans-4,4'-diaminostilbene-2,2'-disulfonic acid / ethyl acetate

With trans-4,4'-diaminostilbene-2,2'-disulfonic acid; potassium carbonate; palladium; In methanol; ethyl acetate; acetone;

Reference yield:

: 415897-69-7
[2-hydroxy-2-(4-hydroxyphenyl)cyclopentyl][(methylethyl)sulfonyl]amine

: 415897-75-5
2-[4-(1-fluoro-2-{[(methylethyl)sulfonyl]amino}cyclopentyl)phenoxy]ethanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / ethyl acetate; acetone

2: trans-4,4'-diaminostilbene-2,2'-disulfonic acid / ethyl acetate

With trans-4,4'-diaminostilbene-2,2'-disulfonic acid; potassium carbonate; In ethyl acetate; acetone;