1-(5-chloro-1H-indol-2-yl)-N-cyclohexyl-3-oxo-2-propylisoindoline-1-carboxamide

Base Information

• Chemical Name: 1-(5-chloro-1H-indol-2-yl)-N-cyclohexyl-3-oxo-2-propylisoindoline-1-carboxamide
• CAS No.: 1427311-15-6
• Molecular Formula: C₂₆H₂₈ClN₃O₂
• Molecular Weight: 449.98
• Mol file: 1427311-15-6.mol

Synonyms:1-(5-chloro-1H-indol-2-yl)-N-cyclohexyl-3-oxo-2-propylisoindoline-1-carboxamide

Chemical Property of 1-(5-chloro-1H-indol-2-yl)-N-cyclohexyl-3-oxo-2-propylisoindoline-1-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(5-chloro-1H-indol-2-yl)-N-cyclohexyl-3-oxo-2-propylisoindoline-1-carboxamide

There total 4 articles about 1-(5-chloro-1H-indol-2-yl)-N-cyclohexyl-3-oxo-2-propylisoindoline-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

C26H29ClIN3O2 (1427311-39-4) → 1-(5-chloro-1H-indol-2-yl)-N-cyclohexyl-3-oxo-2-propylisoindoline-1-carboxamide (1427311-15-6)

Guidance literature:

With caesium carbonate; In dimethyl sulfoxide; at 80 ℃; for 0.666667h; regioselective reaction; Microwave irradiation; Sealed tube; Inert atmosphere;

DOI:10.1021/co4001309

Reference yield:

2-Iodobenzoic acid (88-67-5) → 1-(5-chloro-1H-indol-2-yl)-N-cyclohexyl-3-oxo-2-propylisoindoline-1-carboxamide (1427311-15-6)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 72 h / 20 °C

2: caesium carbonate / dimethyl sulfoxide / 0.67 h / 80 °C / Microwave irradiation; Sealed tube; Inert atmosphere

With caesium carbonate; In methanol; dimethyl sulfoxide; 1: |Ugi Condensation;

DOI:10.1021/co4001309

Reference yield:

Cyclohexyl isocyanide (931-53-3) → 1-(5-chloro-1H-indol-2-yl)-N-cyclohexyl-3-oxo-2-propylisoindoline-1-carboxamide (1427311-15-6)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 72 h / 20 °C

2: caesium carbonate / dimethyl sulfoxide / 0.67 h / 80 °C / Microwave irradiation; Sealed tube; Inert atmosphere

With caesium carbonate; In methanol; dimethyl sulfoxide; 1: |Ugi Condensation;

DOI:10.1021/co4001309

upstream raw materials:

2-Iodobenzoic acid

Cyclohexyl isocyanide

5-chloro-1H-indole-2-carbaldehyde

C₂₆H₂₉ClIN₃O₂