Technology Process of benzyl<2,3β,3aβ,5,6,7,8,8aβ-octahydro-4-oxo-4H-cycloheptathiophen-3α-yl>carbamic acid methyl ester 1α-oxide
There total 8 articles about benzyl<2,3β,3aβ,5,6,7,8,8aβ-octahydro-4-oxo-4H-cycloheptathiophen-3α-yl>carbamic acid methyl ester 1α-oxide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 0 ℃;
DOI:10.1021/ja00526a033
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 71 percent / triethylamine / acetonitrile / 2 h / 25 °C / edducts were added at 0 deg C
2: 1.) sodium ethoxide / 1.) ethanol, reflux, 0.25 h, 2.) 2 h
3: 100 percent / p-toluenesulfonic acid hydrate / acetone; H2O / 1 h / Heating
4: 66 percent / triethylamine / acetonitrile / 2 h / Heating
5: 96 percent / zinc, acetic acid / H2O / 18 h / 70 °C
6: 46 percent / NaHCO3 / methanol / 1 h / 25 °C
7: 89 percent / dimethyl sulfoxide, acetic anhydride / Ambient temperature
8: 100 percent / MCPBA, sodium bicarbonate / CH2Cl2 / 0 °C
With
sodium ethanolate; acetic anhydride; sodium hydrogencarbonate; toluene-4-sulfonic acid; acetic acid; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; zinc;
In
methanol; dichloromethane; water; acetone; acetonitrile;
DOI:10.1021/ja00526a033
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) sodium ethoxide / 1.) ethanol, reflux, 0.25 h, 2.) 2 h
2: 100 percent / p-toluenesulfonic acid hydrate / acetone; H2O / 1 h / Heating
3: 66 percent / triethylamine / acetonitrile / 2 h / Heating
4: 96 percent / zinc, acetic acid / H2O / 18 h / 70 °C
5: 46 percent / NaHCO3 / methanol / 1 h / 25 °C
6: 89 percent / dimethyl sulfoxide, acetic anhydride / Ambient temperature
7: 100 percent / MCPBA, sodium bicarbonate / CH2Cl2 / 0 °C
With
sodium ethanolate; acetic anhydride; sodium hydrogencarbonate; toluene-4-sulfonic acid; acetic acid; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; zinc;
In
methanol; dichloromethane; water; acetone; acetonitrile;
DOI:10.1021/ja00526a033
