N-((1-(2-(3-(1H-pyrazol-1-yl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-3-(4-fluorobenzoxy)-5-methoxybenzamide

Base Information

Chemical Name:N-((1-(2-(3-(1H-pyrazol-1-yl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-3-(4-fluorobenzoxy)-5-methoxybenzamide
CAS No.:1428580-75-9
Molecular Formula:C₃₄H₃₃FN₆O₃
Molecular Weight:592.673
Hs Code.:

Synonyms:N-((1-(2-(3-(1H-pyrazol-1-yl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-3-(4-fluorobenzoxy)-5-methoxybenzamide

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Chemical Property of N-((1-(2-(3-(1H-pyrazol-1-yl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-3-(4-fluorobenzoxy)-5-methoxybenzamide

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Technology Process of N-((1-(2-(3-(1H-pyrazol-1-yl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-3-(4-fluorobenzoxy)-5-methoxybenzamide

There total 3 articles about N-((1-(2-(3-(1H-pyrazol-1-yl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-3-(4-fluorobenzoxy)-5-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428580-73-7
N-((1-(2-(3-(1H-pyrazol-1-yl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-3-hydroxy-5-methoxybenzamide

: 352-11-4
1-chloromethyl-4-fluorobenzene

: 1428580-75-9
N-((1-(2-(3-(1H-pyrazol-1-yl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-3-(4-fluorobenzoxy)-5-methoxybenzamide

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 5h;

Reference yield:

: 63987-23-5
3-(benzoxy)-5-methoxybenzoic acid

: 1428580-75-9
N-((1-(2-(3-(1H-pyrazol-1-yl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-3-(4-fluorobenzoxy)-5-methoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

2: palladium 10% on activated carbon; ammonium formate / methanol / 18 h / Reflux

3: caesium carbonate / N,N-dimethyl-formamide / 5 h / 40 °C

With palladium 10% on activated carbon; ammonium formate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In methanol; N,N-dimethyl-formamide;

Reference yield:

: N-((1-(2-(3-(1H-pyrazol-1-yl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-3-(benzoxy)-5-methoxybenzamide

: 1428580-75-9
N-((1-(2-(3-(1H-pyrazol-1-yl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-3-(4-fluorobenzoxy)-5-methoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; ammonium formate / methanol / 18 h / Reflux

2: caesium carbonate / N,N-dimethyl-formamide / 5 h / 40 °C

With palladium 10% on activated carbon; ammonium formate; caesium carbonate; In methanol; N,N-dimethyl-formamide;