(E)-(R)-6-(tert-Butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-hex-2-enal

Base Information

Chemical Name:(E)-(R)-6-(tert-Butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-hex-2-enal
CAS No.:327027-71-4
Molecular Formula:C₃₀H₃₆O₄Si
Molecular Weight:488.699
Hs Code.:

Synonyms:(E)-(R)-6-(tert-Butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-hex-2-enal

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Chemical Property of (E)-(R)-6-(tert-Butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-hex-2-enal

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Technology Process of (E)-(R)-6-(tert-Butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-hex-2-enal

There total 5 articles about (E)-(R)-6-(tert-Butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-hex-2-enal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 327027-75-8
(E)-(R)-6-(tert-Butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-hex-2-enoic acid methyl ester

: 327027-71-4
(E)-(R)-6-(tert-Butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-hex-2-enal

Guidance literature:: (E)-(R)-6-(tert-Butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-hex-2-enoic acid methyl ester; With diisobutylaluminium hydride; In dichloromethane; at -78 ℃;

With Dess-Martin periodane; Further stages.;
DOI:10.1021/ol000342+

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 327027-71-4
(E)-(R)-6-(tert-Butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-hex-2-enal

Guidance literature:: Multi-step reaction with 5 steps

1.1: imidazole / CH₂Cl₂ / 20 °C

2.1: TfOH / diethyl ether

3.1: DIBAL / CH₂Cl₂ / -100 °C

4.1: i-Pr₂NEt; LiCl / acetonitrile / 20 °C

5.1: DIBAL / CH₂Cl₂ / -78 °C

5.2: 82 percent / Dess-Martin periodinane

With 1H-imidazole; trifluorormethanesulfonic acid; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; lithium chloride; In diethyl ether; dichloromethane; acetonitrile; 4.1: Masamune-Roush HWE reaction;
DOI:10.1021/ol000342+

Reference yield:

: 159801-08-8
methyl (3R)-4-(tert-butyldiphenylsilyloxy)-3-hydroxybutanoate

: 327027-71-4
(E)-(R)-6-(tert-Butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-hex-2-enal

Guidance literature:: Multi-step reaction with 4 steps

1.1: TfOH / diethyl ether

2.1: DIBAL / CH₂Cl₂ / -100 °C

3.1: i-Pr₂NEt; LiCl / acetonitrile / 20 °C

4.1: DIBAL / CH₂Cl₂ / -78 °C

4.2: 82 percent / Dess-Martin periodinane

With trifluorormethanesulfonic acid; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; lithium chloride; In diethyl ether; dichloromethane; acetonitrile; 3.1: Masamune-Roush HWE reaction;
DOI:10.1021/ol000342+