(E)-2-((2R,3R)-2-Benzenesulfonylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-4-chloro-3-(toluene-4-sulfonyloxy)-but-2-enoic acid 4-methoxy-benzyl ester

Base Information

Chemical Name:(E)-2-((2R,3R)-2-Benzenesulfonylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-4-chloro-3-(toluene-4-sulfonyloxy)-but-2-enoic acid 4-methoxy-benzyl ester
CAS No.:186527-79-7
Molecular Formula:C₃₆H₃₃ClN₂O₁₀S₃
Molecular Weight:785.316
Hs Code.:

(E)-2-((2R,3R)-2-Benzenesulfonylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-4-chloro-3-(toluene-4-sulfonyloxy)-but-2-enoic acid 4-methoxy-benzyl ester

Synonyms:(E)-2-((2R,3R)-2-Benzenesulfonylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-4-chloro-3-(toluene-4-sulfonyloxy)-but-2-enoic acid 4-methoxy-benzyl ester

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Chemical Property of (E)-2-((2R,3R)-2-Benzenesulfonylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-4-chloro-3-(toluene-4-sulfonyloxy)-but-2-enoic acid 4-methoxy-benzyl ester

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Technology Process of (E)-2-((2R,3R)-2-Benzenesulfonylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-4-chloro-3-(toluene-4-sulfonyloxy)-but-2-enoic acid 4-methoxy-benzyl ester

There total 2 articles about (E)-2-((2R,3R)-2-Benzenesulfonylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-4-chloro-3-(toluene-4-sulfonyloxy)-but-2-enoic acid 4-methoxy-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 131857-34-6
(E)-2-((2R,3R)-2-Benzenesulfonylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-4-chloro-3-hydroxy-but-2-enoic acid 4-methoxy-benzyl ester

: 98-59-9
p-toluenesulfonyl chloride

: 186527-79-7
(E)-2-((2R,3R)-2-Benzenesulfonylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-4-chloro-3-(toluene-4-sulfonyloxy)-but-2-enoic acid 4-methoxy-benzyl ester

Guidance literature:: With sodium carbonate; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1039/CC9960002705

Reference yield: 9.0%

: 131857-34-6
(E)-2-((2R,3R)-2-Benzenesulfonylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-4-chloro-3-hydroxy-but-2-enoic acid 4-methoxy-benzyl ester

: 98-59-9
p-toluenesulfonyl chloride

: 186527-79-7
(E)-2-((2R,3R)-2-Benzenesulfonylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-4-chloro-3-(toluene-4-sulfonyloxy)-but-2-enoic acid 4-methoxy-benzyl ester

: 183194-06-1
p-methoxybenzyl (Z)-3-chloro-4-{[(p-methylphenyl)sulfonyl]oxy}-2-{2-oxo-3-(phenylacetamido)-4-[(phenylsulfonyl)thio]azetidin-1-yl}-2-butenoate

Guidance literature:: With sodium carbonate; In N,N-dimethyl-formamide; at 0 ℃; for 2h;
DOI:10.1021/jo970051n

Reference yield: 80.0%

: 106-95-6
allyl bromide

: 186527-79-7
(E)-2-((2R,3R)-2-Benzenesulfonylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-4-chloro-3-(toluene-4-sulfonyloxy)-but-2-enoic acid 4-methoxy-benzyl ester

: p-methoxybenzyl 3-allyl-7-(phenylacetamido)-Δ³-cephem-4-carboxylate

: (5R,6R)-3-Methylene-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-methoxy-benzyl ester

Guidance literature:: With manganese; aluminium trichloride; dichloro(2,2'-bipyridine)nickel(II); In 1-methyl-pyrrolidin-2-one; at 20 - 25 ℃; for 2h;
DOI:10.3987/COM-99-S59