5'-O-(4,4'-dimethoxytrityl)-N²-isobutyryl-N¹,N²-bis(isobutyryloxy)ethylenedeoxyguanosine

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-N²-isobutyryl-N¹,N²-bis(isobutyryloxy)ethylenedeoxyguanosine
• CAS No.: 112154-52-6
• Molecular Formula: C₄₈H₅₂Cl₃N₅O₁₃
• Molecular Weight: 1013.33

Synonyms:5'-O-(4,4'-dimethoxytrityl)-N²-isobutyryl-N¹,N²-bis(isobutyryloxy)ethylenedeoxyguanosine

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-N²-isobutyryl-N¹,N²-bis(isobutyryloxy)ethylenedeoxyguanosine

Chemical Property:

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-N²-isobutyryl-N¹,N²-bis(isobutyryloxy)ethylenedeoxyguanosine

There total 2 articles about 5'-O-(4,4'-dimethoxytrityl)-N²-isobutyryl-N¹,N²-bis(isobutyryloxy)ethylenedeoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

Glyoxal (131543-46-9,107-22-2) + isobutyryl chloride (79-30-1) + 5'-O-(4,4'-dimethoxytrityl)-3'-O-(2,2,2-trichloroethoxycarbonyl)-N2-isobutyryldeoxyguanosine (112154-51-5) → 5'-O-(4,4'-dimethoxytrityl)-N2-isobutyryl-N1,N2-bis(isobutyryloxy)ethylenedeoxyguanosine (112154-52-6)

Guidance literature:

DOI:10.1246/bcsj.60.1407

Reference yield:

5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine (68892-41-1) → 5'-O-(4,4'-dimethoxytrityl)-N2-isobutyryl-N1,N2-bis(isobutyryloxy)ethylenedeoxyguanosine (112154-52-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / pyridine / 2 h / Ambient temperature

2: 92 percent

With pyridine;

DOI:10.1246/bcsj.60.1407

Reference yield: 97.0%

5'-O-(4,4'-dimethoxytrityl)-N2-isobutyryl-N1,N2-bis(isobutyryloxy)ethylenedeoxyguanosine (112154-52-6) → N2-isobutyryl-1,N2-[1,2-di(isobutyryloxy)ethylene]-3',5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine (112154-53-7)

Guidance literature:

With pyridine; zinc; In acetylacetone; for 1h; Ambient temperature;

DOI:10.1246/bcsj.60.1407

upstream raw materials:

Glyoxal

isobutyryl chloride

5'-O-(4,4'-dimethoxytrityl)-3'-O-(2,2,2-trichloroethoxycarbonyl)-N²-isobutyryldeoxyguanosine

5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine

Downstream raw materials:

N₂-isobutyryl-1,N₂-[1,2-di(isobutyryloxy)ethylene]-3',5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine

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