2,2-dichloro-N-((1S,2R)-1-fluoromethyl-2-hydroxy-2-{4-[6-(isopropylaminomethyl)pyridin-3-yl]phenyl}ethyl)acetamide

Base Information

Chemical Name:2,2-dichloro-N-((1S,2R)-1-fluoromethyl-2-hydroxy-2-{4-[6-(isopropylaminomethyl)pyridin-3-yl]phenyl}ethyl)acetamide
CAS No.:1454904-54-1
Molecular Formula:C₂₀H₂₄Cl₂FN₃O₂
Molecular Weight:428.334
Hs Code.:

Synonyms:2,2-dichloro-N-((1S,2R)-1-fluoromethyl-2-hydroxy-2-{4-[6-(isopropylaminomethyl)pyridin-3-yl]phenyl}ethyl)acetamide

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Chemical Property of 2,2-dichloro-N-((1S,2R)-1-fluoromethyl-2-hydroxy-2-{4-[6-(isopropylaminomethyl)pyridin-3-yl]phenyl}ethyl)acetamide

Chemical Property:

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Technology Process of 2,2-dichloro-N-((1S,2R)-1-fluoromethyl-2-hydroxy-2-{4-[6-(isopropylaminomethyl)pyridin-3-yl]phenyl}ethyl)acetamide

There total 9 articles about 2,2-dichloro-N-((1S,2R)-1-fluoromethyl-2-hydroxy-2-{4-[6-(isopropylaminomethyl)pyridin-3-yl]phenyl}ethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1R,2S)-2-amino-3-fluoro-1-{4-[6-(isopropylaminomethyl)pyridin-3-yl]phenyl}propan-1-ol trifluoroacetate

: 535-15-9
ethyl 1,1-dichloroacetate

: 1454904-54-1
2,2-dichloro-N-((1S,2R)-1-fluoromethyl-2-hydroxy-2-{4-[6-(isopropylaminomethyl)pyridin-3-yl]phenyl}ethyl)acetamide

Guidance literature:: With triethylamine; In methanol; at 20 ℃; for 24h;

Reference yield:

: 1052114-46-1
tert-butyl ((1R,2S)-3-fluoro-1-hydroxy-1-(4-iodophenyl)propan-2-yl)carbamate

: 1454904-54-1
2,2-dichloro-N-((1S,2R)-1-fluoromethyl-2-hydroxy-2-{4-[6-(isopropylaminomethyl)pyridin-3-yl]phenyl}ethyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

2: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / Reflux

3: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 4 h / 90 °C / Inert atmosphere

4: dichloromethane / 2 h / 0 - 20 °C

5: triethylamine / methanol / 24 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; caesium carbonate; toluene-4-sulfonic acid; triethylamine; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 1454906-58-1
(4S,5R)-4-fluoromethyl-5-(4-iodophenyl)-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

: 1454904-54-1
2,2-dichloro-N-((1S,2R)-1-fluoromethyl-2-hydroxy-2-{4-[6-(isopropylaminomethyl)pyridin-3-yl]phenyl}ethyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / Reflux

2: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 4 h / 90 °C / Inert atmosphere

3: dichloromethane / 2 h / 0 - 20 °C

4: triethylamine / methanol / 24 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; caesium carbonate; triethylamine; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water;