(S)-2-[((R)-4-Benzyl-2-phenyl-4,5-dihydro-oxazole-4-carbonyl)-amino]-propionic acid benzyl ester

Base Information

Chemical Name:(S)-2-[((R)-4-Benzyl-2-phenyl-4,5-dihydro-oxazole-4-carbonyl)-amino]-propionic acid benzyl ester
CAS No.:182176-28-9
Molecular Formula:C₂₇H₂₆N₂O₄
Molecular Weight:442.514
Hs Code.:

Synonyms:(S)-2-[((R)-4-Benzyl-2-phenyl-4,5-dihydro-oxazole-4-carbonyl)-amino]-propionic acid benzyl ester

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Chemical Property of (S)-2-[((R)-4-Benzyl-2-phenyl-4,5-dihydro-oxazole-4-carbonyl)-amino]-propionic acid benzyl ester

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Technology Process of (S)-2-[((R)-4-Benzyl-2-phenyl-4,5-dihydro-oxazole-4-carbonyl)-amino]-propionic acid benzyl ester

There total 3 articles about (S)-2-[((R)-4-Benzyl-2-phenyl-4,5-dihydro-oxazole-4-carbonyl)-amino]-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 5557-81-3,5557-83-5,34404-37-0
L-alanine benzyl ester hydrochloride

: 182176-26-7
(S)-4-Benzyl-4-bromomethyl-2-phenyl-4H-oxazol-5-one

: 182176-28-9
(S)-2-[((R)-4-Benzyl-2-phenyl-4,5-dihydro-oxazole-4-carbonyl)-amino]-propionic acid benzyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In various solvent(s); at 50 ℃; for 18h; in DMA;
DOI:10.1002/hlca.19960790508

Reference yield:

: 182176-12-1
rac-4-benzyl-4-(iodomethyl)-2-phenyloxazol-5(4H)-one

: 182176-28-9
(S)-2-[((R)-4-Benzyl-2-phenyl-4,5-dihydro-oxazole-4-carbonyl)-amino]-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: ethyldiisopropylamine / various solvent(s) / 24 h / 70 °C

2: 53 percent / 33percent HBr/AcOH, Ac₂O / 8 h / 90 °C / in a sealed tube

3: 85 percent / Et(i-Pr)2N / various solvent(s) / 18 h / 50 °C / in DMA

With hydrogen bromide; acetic anhydride; acetic acid; N-ethyl-N,N-diisopropylamine; In various solvent(s);
DOI:10.1002/hlca.19960790508

Reference yield:

: 182268-01-5
(R)-4-Benzyl-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid ((S)-1-cyclohexylcarbamoyl-2-phenyl-ethyl)-amide

: 182176-28-9
(S)-2-[((R)-4-Benzyl-2-phenyl-4,5-dihydro-oxazole-4-carbonyl)-amino]-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / 33percent HBr/AcOH, Ac₂O / 8 h / 90 °C / in a sealed tube

2: 85 percent / Et(i-Pr)2N / various solvent(s) / 18 h / 50 °C / in DMA

With hydrogen bromide; acetic anhydride; acetic acid; N-ethyl-N,N-diisopropylamine; In various solvent(s);
DOI:10.1002/hlca.19960790508