methyl (S)-(1-{[(2S,3S,5S)-5-amino-3-hydroxy-6-phenyl-1-[4-(pyridin-2-yl)phenyl]hexan-2-yl]amino}-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Base Information

• Chemical Name: methyl (S)-(1-{[(2S,3S,5S)-5-amino-3-hydroxy-6-phenyl-1-[4-(pyridin-2-yl)phenyl]hexan-2-yl]amino}-3,3-dimethyl-1-oxobutan-2-yl)carbamate
• CAS No.: 854755-00-3
• Molecular Formula: C₃₁H₄₀N₄O₄
• Molecular Weight: 532.683

Synonyms:methyl (S)-(1-{[(2S,3S,5S)-5-amino-3-hydroxy-6-phenyl-1-[4-(pyridin-2-yl)phenyl]hexan-2-yl]amino}-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Chemical Property of methyl (S)-(1-{[(2S,3S,5S)-5-amino-3-hydroxy-6-phenyl-1-[4-(pyridin-2-yl)phenyl]hexan-2-yl]amino}-3,3-dimethyl-1-oxobutan-2-yl)carbamate

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Technology Process of methyl (S)-(1-{[(2S,3S,5S)-5-amino-3-hydroxy-6-phenyl-1-[4-(pyridin-2-yl)phenyl]hexan-2-yl]amino}-3,3-dimethyl-1-oxobutan-2-yl)carbamate

There total 1 articles about methyl (S)-(1-{[(2S,3S,5S)-5-amino-3-hydroxy-6-phenyl-1-[4-(pyridin-2-yl)phenyl]hexan-2-yl]amino}-3,3-dimethyl-1-oxobutan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (1S,3S,4S)-1-benzyl-3-hydroxy-4-({(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}amino)-5-[4-(2-pyridinyl)phenyl]pentylcarbamate → methyl (S)-(1-{[(2S,3S,5S)-5-amino-3-hydroxy-6-phenyl-1-[4-(pyridin-2-yl)phenyl]hexan-2-yl]amino}-3,3-dimethyl-1-oxobutan-2-yl)carbamate (854755-00-3)

Guidance literature:

tert-butyl (1S,3S,4S)-1-benzyl-3-hydroxy-4-({(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}amino)-5-[4-(2-pyridinyl)phenyl]pentylcarbamate; With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 1h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield: 77.0%

(3R,3aS,6aR) and (3S,3aR,6aS)-hexahydrofuro[2,3-b]furan-3-yl 4-nitrophenyl carbonate (854745-99-6,252873-01-1,252873-35-1) + methyl (S)-(1-{[(2S,3S,5S)-5-amino-3-hydroxy-6-phenyl-1-[4-(pyridin-2-yl)phenyl]hexan-2-yl]amino}-3,3-dimethyl-1-oxobutan-2-yl)carbamate (854755-00-3) → (3R,3aS,6aR) and (3S,3aR,6aS)-hexahydrofuro[2,3-b]furan-3-yl (1S,3S,4S)-1-benzyl-3-hydroxy-4-({(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}amino)-5-[4-(2-pyridinyl)phenyl]pentylcarbamate

Guidance literature:

With triethylamine; In tetrahydrofuran; at 25 ℃; for 2h;

Reference yield: 75.0%

methyl (S)-(1-{[(2S,3S,5S)-5-amino-3-hydroxy-6-phenyl-1-[4-(pyridin-2-yl)phenyl]hexan-2-yl]amino}-3,3-dimethyl-1-oxobutan-2-yl)carbamate (854755-00-3) + (2S,3S)-2-{3-[(2-isopropyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}-3-methylpentanoic acid trifluoroacetate (854757-54-3) → methyl (1S)-1-[(3S)-({(1S,2S,4S)-2-hydroxy-4-[((2S)-2-{3-[(2-isopropyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}-3-methylpentanoyl)amino]-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; In tetrahydrofuran; at 25 ℃; for 1h;

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