4-Amino-6-((1-(2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethyl)amino)-5-pyrimidinecarbonitrile

Base Information

Chemical Name:4-Amino-6-((1-(2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethyl)amino)-5-pyrimidinecarbonitrile
CAS No.:1312606-04-4
Molecular Formula:C₂₂H₁₉N₇O₂S
Molecular Weight:445.505
Hs Code.:

Synonyms:4-Amino-6-((1-(2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethyl)amino)-5-pyrimidinecarbonitrile

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Chemical Property of 4-Amino-6-((1-(2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethyl)amino)-5-pyrimidinecarbonitrile

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Technology Process of 4-Amino-6-((1-(2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethyl)amino)-5-pyrimidinecarbonitrile

There total 16 articles about 4-Amino-6-((1-(2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethyl)amino)-5-pyrimidinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312606-03-3
1-(2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethanamine

: 60025-09-4
4-amino-6-chloropyrimidine-5-carbonitrile

: 1312606-04-4
4-Amino-6-((1-(2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethyl)amino)-5-pyrimidinecarbonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 25 - 110 ℃;

Reference yield:

: 5470-18-8,34515-82-7
2-Chloro-3-nitropyridine

: 1312606-04-4
4-Amino-6-((1-(2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethyl)amino)-5-pyrimidinecarbonitrile

Guidance literature:: Multi-step reaction with 10 steps

1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 110 °C / Inert atmosphere

2: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tetrahydrofuran / 5 h / 25 °C

3: hydrogen / palladium on carbon / ethanol / Inert atmosphere

4: cerium(III) chloride heptahydrate / 3 h / 100 °C

5: diisobutylaluminium hydride / dichloromethane / 4 h / -78 °C

6: dipyridinium dichromate / dichloromethane / 25 °C

7: tetrahydrofuran / 2 h / 0 °C

8: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 °C

9: hydrazine hydrate / ethanol / 25 °C

10: N-ethyl-N,N-diisopropylamine / butan-1-ol / 25 - 110 °C

With osmium(VIII) oxide; dipyridinium dichromate; cerium(III) chloride heptahydrate; di-isopropyl azodicarboxylate; water; hydrogen; diisobutylaluminium hydride; hydrazine hydrate; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; palladium on carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; butan-1-ol;

Reference yield:

: 150281-83-7
2-ethenyl-3-nitropyridine

: 1312606-04-4
4-Amino-6-((1-(2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethyl)amino)-5-pyrimidinecarbonitrile

Guidance literature:: Multi-step reaction with 9 steps

1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tetrahydrofuran / 5 h / 25 °C

2: hydrogen / palladium on carbon / ethanol / Inert atmosphere

3: cerium(III) chloride heptahydrate / 3 h / 100 °C

4: diisobutylaluminium hydride / dichloromethane / 4 h / -78 °C

5: dipyridinium dichromate / dichloromethane / 25 °C

6: tetrahydrofuran / 2 h / 0 °C

7: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 °C

8: hydrazine hydrate / ethanol / 25 °C

9: N-ethyl-N,N-diisopropylamine / butan-1-ol / 25 - 110 °C

With osmium(VIII) oxide; dipyridinium dichromate; cerium(III) chloride heptahydrate; di-isopropyl azodicarboxylate; water; hydrogen; diisobutylaluminium hydride; hydrazine hydrate; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; palladium on carbon; In tetrahydrofuran; ethanol; dichloromethane; butan-1-ol;