(Z)-4-((4-benzyl-2,3-dihydro-1H-1,5-benzodiazepine-1-yl)methyl)benzonitrile

Base Information

Chemical Name:(Z)-4-((4-benzyl-2,3-dihydro-1H-1,5-benzodiazepine-1-yl)methyl)benzonitrile
CAS No.:1632039-13-4
Molecular Formula:C₂₄H₂₁N₃
Molecular Weight:351.451
Hs Code.:

Synonyms:(Z)-4-((4-benzyl-2,3-dihydro-1H-1,5-benzodiazepine-1-yl)methyl)benzonitrile

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Chemical Property of (Z)-4-((4-benzyl-2,3-dihydro-1H-1,5-benzodiazepine-1-yl)methyl)benzonitrile

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Technology Process of (Z)-4-((4-benzyl-2,3-dihydro-1H-1,5-benzodiazepine-1-yl)methyl)benzonitrile

There total 9 articles about (Z)-4-((4-benzyl-2,3-dihydro-1H-1,5-benzodiazepine-1-yl)methyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1632039-01-0
(S)-tert-butyl 2-(1-phenylbut-3-en-2-ylamino)phenylcarbamate

: 105-07-7
4-cyanobenzaldehyde

: 1632039-13-4
(Z)-4-((4-benzyl-2,3-dihydro-1H-1,5-benzodiazepine-1-yl)methyl)benzonitrile

Guidance literature:: (S)-tert-butyl 2-(1-phenylbut-3-en-2-ylamino)phenylcarbamate; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 0.333333h;

4-cyanobenzaldehyde; In dichloromethane; at 20 ℃;
DOI:10.1055/s-0033-1340837

Reference yield:

: 1632038-97-1
(S)-tert-butyl 2-(1-hydroxy-3-phenylpropan-2-ylamino)phenylcarbamate

: 1632039-13-4
(Z)-4-((4-benzyl-2,3-dihydro-1H-1,5-benzodiazepine-1-yl)methyl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C

1.2: 1 h / -78 °C

2.1: potassium hexamethylsilazane; methyl-triphenylphosphonium iodide / tetrahydrofuran / 1 h / -78 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 0.33 h / 0 - 20 °C

3.2: 20 °C

With oxalyl dichloride; methyl-triphenylphosphonium iodide; potassium hexamethylsilazane; dimethyl sulfoxide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1.1: |Swern Oxidation / 1.2: |Swern Oxidation / 2.1: |Wittig Olefination;
DOI:10.1055/s-0033-1340837

Reference yield:

: 1632038-99-3
C₂₀H₂₄N₂O₃

: 1632039-13-4
(Z)-4-((4-benzyl-2,3-dihydro-1H-1,5-benzodiazepine-1-yl)methyl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hexamethylsilazane; methyl-triphenylphosphonium iodide / tetrahydrofuran / 1 h / -78 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 0.33 h / 0 - 20 °C

2.2: 20 °C

With methyl-triphenylphosphonium iodide; potassium hexamethylsilazane; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1.1: |Wittig Olefination;
DOI:10.1055/s-0033-1340837