4-{3-[4-(3-(2-hydroxycarbonyl-ethyl)-5-phenyl-pyrazol-1-yl)-3-methyl-phenyl]-propargylamino}benzamidine

Base Information

Chemical Name:4-{3-[4-(3-(2-hydroxycarbonyl-ethyl)-5-phenyl-pyrazol-1-yl)-3-methyl-phenyl]-propargylamino}benzamidine
CAS No.:276675-48-0
Molecular Formula:C₂₉H₂₇N₅O₂
Molecular Weight:477.566
Hs Code.:

Synonyms:4-{3-[4-(3-(2-hydroxycarbonyl-ethyl)-5-phenyl-pyrazol-1-yl)-3-methyl-phenyl]-propargylamino}benzamidine

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Chemical Property of 4-{3-[4-(3-(2-hydroxycarbonyl-ethyl)-5-phenyl-pyrazol-1-yl)-3-methyl-phenyl]-propargylamino}benzamidine

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Technology Process of 4-{3-[4-(3-(2-hydroxycarbonyl-ethyl)-5-phenyl-pyrazol-1-yl)-3-methyl-phenyl]-propargylamino}benzamidine

There total 8 articles about 4-{3-[4-(3-(2-hydroxycarbonyl-ethyl)-5-phenyl-pyrazol-1-yl)-3-methyl-phenyl]-propargylamino}benzamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 276673-59-7
4-{3-[4-(3-(2-ethoxycarbonyl-ethyl)-5-phenyl-pyrazol-1-yl)-3-methyl-phenyl]-propargylamino}benzamidine

: 276675-48-0
4-{3-[4-(3-(2-hydroxycarbonyl-ethyl)-5-phenyl-pyrazol-1-yl)-3-methyl-phenyl]-propargylamino}benzamidine

Guidance literature:: With lithium hydroxide; ammonium chloride;

Reference yield:

: 276677-15-7
1-(4-iodo-2-methyl-phenyl)-3-(2-hydroxycarbonyl-ethyl)-5-phenyl-pyrazole

: 276675-48-0
4-{3-[4-(3-(2-hydroxycarbonyl-ethyl)-5-phenyl-pyrazol-1-yl)-3-methyl-phenyl]-propargylamino}benzamidine

Guidance literature:: Multi-step reaction with 3 steps

1: 1,1'-carbonyldiimidazole / ethanol; dichloromethane

2: triethylamine; trifluoroacetic acid / tetrakis(triphenylphosphine)palladium ⁽⁰⁾ / acetonitrile

3: lithium hydroxide; ammonium chloride

With lithium hydroxide; ammonium chloride; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; tetrakis(triphenylphosphine)palladium ⁽⁰⁾; In ethanol; dichloromethane; acetonitrile;

Reference yield:

: 276677-06-6
4-propargylamino-benzamidine

: 276675-48-0
4-{3-[4-(3-(2-hydroxycarbonyl-ethyl)-5-phenyl-pyrazol-1-yl)-3-methyl-phenyl]-propargylamino}benzamidine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / tetrahydrofuran

2: triethylamine; trifluoroacetic acid / tetrakis(triphenylphosphine)palladium ⁽⁰⁾ / acetonitrile

3: lithium hydroxide; ammonium chloride

With lithium hydroxide; sodium hydroxide; ammonium chloride; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine)palladium ⁽⁰⁾; In tetrahydrofuran; acetonitrile;