5-azetidin-3-yl-1-(4-difluoromethoxybenzenesulfonyl)-1H-indole hydrochloride

Base Information

Chemical Name:5-azetidin-3-yl-1-(4-difluoromethoxybenzenesulfonyl)-1H-indole hydrochloride
CAS No.:1063992-89-1
Molecular Formula:C₁₈H₁₆F₂N₂O₃S*ClH
Molecular Weight:414.86
Hs Code.:

Synonyms:5-azetidin-3-yl-1-(4-difluoromethoxybenzenesulfonyl)-1H-indole hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-azetidin-3-yl-1-(4-difluoromethoxybenzenesulfonyl)-1H-indole hydrochloride

Chemical Property:

Purity/Quality:

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Technology Process of 5-azetidin-3-yl-1-(4-difluoromethoxybenzenesulfonyl)-1H-indole hydrochloride

There total 3 articles about 5-azetidin-3-yl-1-(4-difluoromethoxybenzenesulfonyl)-1H-indole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1063993-08-7
5-azetidin-3-yl-1-(4-difluoromethoxybenzenesulfonyl)-1H-indole

: 1063992-89-1
5-azetidin-3-yl-1-(4-difluoromethoxybenzenesulfonyl)-1H-indole hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether;

Reference yield:

: 351003-34-4
4-[(difluoromethyl)oxy]benzenesulfonyl chloride

: 1063992-89-1
5-azetidin-3-yl-1-(4-difluoromethoxybenzenesulfonyl)-1H-indole hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

1.2: 0.75 h

2.1: chloro-trimethyl-silane; ethylene dibromide; zinc / ISOPROPYLAMIDE / 0.5 h / 20 - 65 °C

2.2: 1 h / 80 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.1: hydrogenchloride / diethyl ether

With hydrogenchloride; chloro-trimethyl-silane; sodium hydride; ethylene dibromide; trifluoroacetic acid; zinc; In diethyl ether; dichloromethane; ISOPROPYLAMIDE; N,N-dimethyl-formamide;

Reference yield:

: 16066-91-4
5-iodo-1H-indole

: 1063992-89-1
5-azetidin-3-yl-1-(4-difluoromethoxybenzenesulfonyl)-1H-indole hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

1.2: 0.75 h

2.1: chloro-trimethyl-silane; ethylene dibromide; zinc / ISOPROPYLAMIDE / 0.5 h / 20 - 65 °C

2.2: 1 h / 80 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.1: hydrogenchloride / diethyl ether

With hydrogenchloride; chloro-trimethyl-silane; sodium hydride; ethylene dibromide; trifluoroacetic acid; zinc; In diethyl ether; dichloromethane; ISOPROPYLAMIDE; N,N-dimethyl-formamide;