Trimethylsilanyl-thioacetic acid S-((S)-1-{1-[(E)-4-nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-yl) ester

Base Information

• Chemical Name: Trimethylsilanyl-thioacetic acid S-((S)-1-{1-[(E)-4-nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-yl) ester
• CAS No.: 97033-05-1
• Molecular Formula: C₁₉H₂₇N₃O₅SSi
• Molecular Weight: 437.592
• Mol file: 97033-05-1.mol

Synonyms:Trimethylsilanyl-thioacetic acid S-((S)-1-{1-[(E)-4-nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-yl) ester

Chemical Property of Trimethylsilanyl-thioacetic acid S-((S)-1-{1-[(E)-4-nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-yl) ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of Trimethylsilanyl-thioacetic acid S-((S)-1-{1-[(E)-4-nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-yl) ester

There total 1 articles about Trimethylsilanyl-thioacetic acid S-((S)-1-{1-[(E)-4-nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-yl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

trimethylsilylacetic acid (2345-38-2) + (S)-3-mercapto-1-pyrrolidine (90505-36-5) → Trimethylsilanyl-thioacetic acid S-((S)-1-{1-[(E)-4-nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-yl) ester (97033-05-1)

Guidance literature:

With dicyclohexyl-carbodiimide; dmap; In pyridine; benzene; for 13h; Ambient temperature;

DOI:10.1016/S0040-4039(00)89176-5

Reference yield: 58.0%

Trimethylsilanyl-thioacetic acid S-((S)-1-{1-[(E)-4-nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-yl) ester (97033-05-1) + Acetic acid (2R,3R)-3-[(R)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-1-trimethylsilanyl-azetidin-2-yl ester (97033-08-4) → {(2R,3S)-3-[(R)-1-(4-Nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-2-yl}-thioacetic acid S-(1-{1-[(E)-4-nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-yl) ester (97033-09-5)

Guidance literature:

trimethylsilyl trifluoromethanesulfonate; In dichloromethane; for 28h; Mechanism; Ambient temperature;

DOI:10.1016/S0040-4039(00)89176-5

upstream raw materials:

trimethylsilylacetic acid

(S)-3-mercapto-1-pyrrolidine

Downstream raw materials:

{(2R,3S)-3-[(R)-1-(4-Nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-2-yl}-thioacetic acid S-(1-{1-[(E)-4-nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-yl) ester