{3-Benzyloxy-2-[(3S,4R)-3-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-3-methyl-pent-1-ynyl]-5,6-dimethoxy-4-methyl-phenyl}-acetic acid methyl ester

Base Information

Chemical Name:{3-Benzyloxy-2-[(3S,4R)-3-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-3-methyl-pent-1-ynyl]-5,6-dimethoxy-4-methyl-phenyl}-acetic acid methyl ester
CAS No.:217486-24-3
Molecular Formula:C₃₂H₄₆O₇Si
Molecular Weight:570.799
Hs Code.:

{3-Benzyloxy-2-[(3S,4R)-3-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-3-methyl-pent-1-ynyl]-5,6-dimethoxy-4-methyl-phenyl}-acetic acid methyl ester

Synonyms:{3-Benzyloxy-2-[(3S,4R)-3-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-3-methyl-pent-1-ynyl]-5,6-dimethoxy-4-methyl-phenyl}-acetic acid methyl ester

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Chemical Property of {3-Benzyloxy-2-[(3S,4R)-3-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-3-methyl-pent-1-ynyl]-5,6-dimethoxy-4-methyl-phenyl}-acetic acid methyl ester

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Technology Process of {3-Benzyloxy-2-[(3S,4R)-3-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-3-methyl-pent-1-ynyl]-5,6-dimethoxy-4-methyl-phenyl}-acetic acid methyl ester

There total 8 articles about {3-Benzyloxy-2-[(3S,4R)-3-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-3-methyl-pent-1-ynyl]-5,6-dimethoxy-4-methyl-phenyl}-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 217486-16-3
(2R,3S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methyl-pent-4-yn-2-ol

: 217486-22-1
(3-Benzyloxy-2-iodo-5,6-dimethoxy-4-methyl-phenyl)-acetic acid methyl ester

: 217486-24-3
{3-Benzyloxy-2-[(3S,4R)-3-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-3-methyl-pent-1-ynyl]-5,6-dimethoxy-4-methyl-phenyl}-acetic acid methyl ester

Guidance literature:: With palladium diacetate; copper(l) iodide; diethylamine; triphenylphosphine; In dimethyl sulfoxide; at 90 ℃; for 12h;
DOI:10.1021/ja982403t

Reference yield:

: 105104-12-9
4-(benzyloxy)-2-methoxy-3-methylphenol

: 217486-24-3
{3-Benzyloxy-2-[(3S,4R)-3-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-3-methyl-pent-1-ynyl]-5,6-dimethoxy-4-methyl-phenyl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / Et₂AlCl / CH₂Cl₂ / 17 h / 25 °C

2: 92 percent / K₂CO₃ / acetone / 9 h / Heating

3: 94 percent / I₂, AgOCOCF₃ / CHCl₃ / 1 h / 0 °C

4: 92 percent / PDC, pyridine / CH₂Cl₂ / 41 h / 25 °C

5: 1.) n-BuLi / 2.) THF, from -78 deg C to 25 deg C

6: AgNO₃ / 1 h / 60 °C

7: 98 percent / PPh₃, Pd(OAc)2, Et₂NH, CuI / dimethylsulfoxide / 12 h / 90 °C

With pyridine; palladium diacetate; copper(l) iodide; dipyridinium dichromate; n-butyllithium; iodine; silver trifluoroacetate; diethylaluminium chloride; potassium carbonate; silver nitrate; diethylamine; triphenylphosphine; In dichloromethane; chloroform; dimethyl sulfoxide; acetone;
DOI:10.1021/ja982403t

Reference yield:

: 217486-14-1
(2S,3R)-2-Methyl-2-trimethylsilanylethynyl-butane-1,3-diol

: 217486-24-3
{3-Benzyloxy-2-[(3S,4R)-3-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-3-methyl-pent-1-ynyl]-5,6-dimethoxy-4-methyl-phenyl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / KF, MeOH / 1 h / 60 °C

2: 99 percent / imidazole / dimethylformamide / 0.5 h / Ambient temperature

3: 98 percent / PPh₃, Pd(OAc)2, Et₂NH, CuI / dimethylsulfoxide / 12 h / 90 °C

With 1H-imidazole; methanol; palladium diacetate; potassium fluoride; copper(l) iodide; diethylamine; triphenylphosphine; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ja982403t