Technology Process of N-(diethylphosphoryl)-L-isoleucyl-O-(tetrahydro-2-pyranyl)-L-tyrosylglycine ethyl ester
There total 3 articles about N-(diethylphosphoryl)-L-isoleucyl-O-(tetrahydro-2-pyranyl)-L-tyrosylglycine ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 85 percent / pyridinium p-toluenesulfonate / CH2Cl2 / 72 h / 35 °C
2: 93 percent / H2 / 10percent Pd/C / methanol / 3 h / 760 Torr
3: 1.) N,N'-carbonyldiimidazole, 2.) / 1.) DMF, -10 deg C, 2.) RT, 3 h
With
hydrogen; pyridinium p-toluenesulfonate; 1,1'-carbonyldiimidazole;
palladium on activated charcoal;
In
methanol; dichloromethane;
DOI:10.1021/jm00163a044
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 85 percent / pyridinium p-toluenesulfonate / CH2Cl2 / 72 h / 35 °C
2: 93 percent / H2 / 10percent Pd/C / methanol / 3 h / 760 Torr
3: 1.) N,N'-carbonyldiimidazole, 2.) / 1.) DMF, -10 deg C, 2.) RT, 3 h
With
hydrogen; pyridinium p-toluenesulfonate; 1,1'-carbonyldiimidazole;
palladium on activated charcoal;
In
methanol; dichloromethane;
DOI:10.1021/jm00163a044
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 81 percent / 2,6-lutidine / CH2Cl2 / 2 h / -15 - 20 °C
2: 96 percent / H2 / 10percent Pd/C / methanol / 760 Torr
3: 1.) N,N'-carbonyldiimidazole, 2.) / 1.) DMF, -10 deg C, 2.) RT, 3 h
With
2,6-dimethylpyridine; hydrogen; 1,1'-carbonyldiimidazole;
palladium on activated charcoal;
In
methanol; dichloromethane;
DOI:10.1021/jm00163a044
