N-(diethylphosphoryl)-L-isoleucyl-O-(tetrahydro-2-pyranyl)-L-tyrosylglycine ethyl ester

Base Information

Chemical Name:N-(diethylphosphoryl)-L-isoleucyl-O-(tetrahydro-2-pyranyl)-L-tyrosylglycine ethyl ester
CAS No.:122900-01-0
Molecular Formula:C₂₈H₄₆N₃O₉P
Molecular Weight:599.662
Hs Code.:

Synonyms:N-(diethylphosphoryl)-L-isoleucyl-O-(tetrahydro-2-pyranyl)-L-tyrosylglycine ethyl ester

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Chemical Property of N-(diethylphosphoryl)-L-isoleucyl-O-(tetrahydro-2-pyranyl)-L-tyrosylglycine ethyl ester

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Technology Process of N-(diethylphosphoryl)-L-isoleucyl-O-(tetrahydro-2-pyranyl)-L-tyrosylglycine ethyl ester

There total 3 articles about N-(diethylphosphoryl)-L-isoleucyl-O-(tetrahydro-2-pyranyl)-L-tyrosylglycine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 122900-01-0
N-(diethylphosphoryl)-L-isoleucyl-O-(tetrahydro-2-pyranyl)-L-tyrosylglycine ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 72 h / 35 °C

2: 93 percent / H₂ / 10percent Pd/C / methanol / 3 h / 760 Torr

3: 1.) N,N'-carbonyldiimidazole, 2.) / 1.) DMF, -10 deg C, 2.) RT, 3 h

With hydrogen; pyridinium p-toluenesulfonate; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm00163a044

Reference yield:

: 41888-91-9
N-CBZ-L-tyrosylglycine ethyl ester

: 122900-01-0
N-(diethylphosphoryl)-L-isoleucyl-O-(tetrahydro-2-pyranyl)-L-tyrosylglycine ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 72 h / 35 °C

2: 93 percent / H₂ / 10percent Pd/C / methanol / 3 h / 760 Torr

3: 1.) N,N'-carbonyldiimidazole, 2.) / 1.) DMF, -10 deg C, 2.) RT, 3 h

With hydrogen; pyridinium p-toluenesulfonate; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm00163a044

Reference yield:

: 103310-88-9
L-isoleucine benzyl ester hydrochloride

: 122900-01-0
N-(diethylphosphoryl)-L-isoleucyl-O-(tetrahydro-2-pyranyl)-L-tyrosylglycine ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / -15 - 20 °C

2: 96 percent / H₂ / 10percent Pd/C / methanol / 760 Torr

3: 1.) N,N'-carbonyldiimidazole, 2.) / 1.) DMF, -10 deg C, 2.) RT, 3 h

With 2,6-dimethylpyridine; hydrogen; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm00163a044