Technology Process of 1-(3-benzyl-5-[1,2,4]triazol-1-ylmethylphenyl)-3-(4-methylpyridin-2-yl)-propane-1,3-dione
There total 11 articles about 1-(3-benzyl-5-[1,2,4]triazol-1-ylmethylphenyl)-3-(4-methylpyridin-2-yl)-propane-1,3-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium ethanolate;
In
tetrahydrofuran;
at 20 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: -butyl vinyl ether; triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / DMF (N,N-dimethyl-formamide) / 100 °C
1.2: 3 h / 20 °C
2.1: sodium ethanolate / tetrahydrofuran / 4 h / 20 °C
With
-butyl vinyl ether; sodium ethanolate; triethylamine;
1,3-bis-(diphenylphosphino)propane; palladium diacetate;
In
tetrahydrofuran; DMF (N,N-dimethyl-formamide);
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: n-butyllithium / hexanes; diethyl ether / 0.5 h / -78 °C
1.2: -78 - 0 °C
2.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 20 °C
3.1: tetrahydrofuran; hexanes / 1 h / -78 °C
3.2: -78 - 20 °C
4.1: sodium tetrahydroborate / methanol / 3 h / 20 °C
5.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 20 °C
6.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 0.17 h / 20 °C
6.2: 20 °C
7.1: -butyl vinyl ether; triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / DMF (N,N-dimethyl-formamide) / 100 °C
7.2: 3 h / 20 °C
8.1: sodium ethanolate / tetrahydrofuran / 4 h / 20 °C
With
triethylsilane; sodium tetrahydroborate; n-butyllithium; -butyl vinyl ether; carbon tetrabromide; boron trifluoride diethyl etherate; sodium ethanolate; sodium hydride; triethylamine; triphenylphosphine;
1,3-bis-(diphenylphosphino)propane; palladium diacetate;
In
tetrahydrofuran; methanol; hexanes; DMF (N,N-dimethyl-formamide); diethyl ether; dichloromethane;
