1,2-dihydro-5-<4-(1H-imidazol-1-yl)phenyl>-6-methyl-2-oxo-3-pyridinecarboxylic acid

Base Information

Chemical Name:1,2-dihydro-5-<4-(1H-imidazol-1-yl)phenyl>-6-methyl-2-oxo-3-pyridinecarboxylic acid
CAS No.:108122-67-4
Molecular Formula:C₁₆H₁₃N₃O₃
Molecular Weight:295.298
Hs Code.:

Synonyms:1,2-dihydro-5-<4-(1H-imidazol-1-yl)phenyl>-6-methyl-2-oxo-3-pyridinecarboxylic acid

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Chemical Property of 1,2-dihydro-5-<4-(1H-imidazol-1-yl)phenyl>-6-methyl-2-oxo-3-pyridinecarboxylic acid

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Technology Process of 1,2-dihydro-5-<4-(1H-imidazol-1-yl)phenyl>-6-methyl-2-oxo-3-pyridinecarboxylic acid

There total 5 articles about 1,2-dihydro-5-<4-(1H-imidazol-1-yl)phenyl>-6-methyl-2-oxo-3-pyridinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 90514-66-2
1,2-dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-6-methyl-2-oxo-3-pyridinecarbonitrile

: 108122-67-4
1,2-dihydro-5-<4-(1H-imidazol-1-yl)phenyl>-6-methyl-2-oxo-3-pyridinecarboxylic acid

Guidance literature:: With sulfuric acid; at 100 ℃; for 8h;
DOI:10.1021/jm00389a011

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 108122-67-4
1,2-dihydro-5-<4-(1H-imidazol-1-yl)phenyl>-6-methyl-2-oxo-3-pyridinecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 33 percent / K₂CO₃ / pyridine / 18 h / Heating

2: 54 percent / β-alanine / butan-1-ol / 9 h / Heating

3: 50 percent / Fe, FeCl₃, 12 N HCl / methanol; H₂O / 4 h / Heating

4: acetonitrile / 1.) RT, overnight, 2.) reflux, 1.5 h

5: CH₃ONa / dimethylformamide / 3 h / 100 °C

6: 33 percent / 50percent aq. H₂SO₄ / 8 h / 100 °C

With hydrogenchloride; sulfuric acid; sodium methylate; iron(III) chloride; iron; potassium carbonate; 3-amino propanoic acid; In pyridine; methanol; water; N,N-dimethyl-formamide; acetonitrile; butan-1-ol;
DOI:10.1021/jm00389a011

Reference yield:

: 90514-68-4
1-[4-(1H-imidazol-1-yl)phenyl]-2-propanone

: 108122-67-4
1,2-dihydro-5-<4-(1H-imidazol-1-yl)phenyl>-6-methyl-2-oxo-3-pyridinecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 1.) RT, overnight, 2.) reflux, 1.5 h

2: CH₃ONa / dimethylformamide / 3 h / 100 °C

3: 33 percent / 50percent aq. H₂SO₄ / 8 h / 100 °C

With sulfuric acid; sodium methylate; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00389a011