9-hydroxy-5-(3,4,5-trimethoxy-phenyl)-7,8,8a,9-tetrahydro-5H-1,3-dioxa-5a-aza-dicyclopenta[b,g]naphthalen-6-one

Base Information

Chemical Name:9-hydroxy-5-(3,4,5-trimethoxy-phenyl)-7,8,8a,9-tetrahydro-5H-1,3-dioxa-5a-aza-dicyclopenta[b,g]naphthalen-6-one
CAS No.:257628-95-8
Molecular Formula:C₂₂H₂₃NO₇
Molecular Weight:413.427
Hs Code.:

9-hydroxy-5-(3,4,5-trimethoxy-phenyl)-7,8,8a,9-tetrahydro-5<i>H</i>-1,3-dioxa-5a-aza-dicyclopenta[<i>b</i>,<i>g</i>]naphthalen-6-one

Synonyms:9-hydroxy-5-(3,4,5-trimethoxy-phenyl)-7,8,8a,9-tetrahydro-5H-1,3-dioxa-5a-aza-dicyclopenta[b,g]naphthalen-6-one

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Chemical Property of 9-hydroxy-5-(3,4,5-trimethoxy-phenyl)-7,8,8a,9-tetrahydro-5H-1,3-dioxa-5a-aza-dicyclopenta[b,g]naphthalen-6-one

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Technology Process of 9-hydroxy-5-(3,4,5-trimethoxy-phenyl)-7,8,8a,9-tetrahydro-5H-1,3-dioxa-5a-aza-dicyclopenta[b,g]naphthalen-6-one

There total 3 articles about 9-hydroxy-5-(3,4,5-trimethoxy-phenyl)-7,8,8a,9-tetrahydro-5H-1,3-dioxa-5a-aza-dicyclopenta[b,g]naphthalen-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 257628-86-7
7,8-methylenedioxy-5-(3',4',5'-trimethoxyphenyl)-1,2,3,5,10,10a-hexahydrobenz[f]indolizine-3,10-dione

: 257628-95-8
9-hydroxy-5-(3,4,5-trimethoxy-phenyl)-7,8,8a,9-tetrahydro-5H-1,3-dioxa-5a-aza-dicyclopenta[b,g]naphthalen-6-one

Guidance literature:: With lithium tri(t-butoxy)aluminum hydride; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1002/jhet.5570360525

Reference yield:

: (R)-N,O-bistrimethylsilylpyroglutamic acid

: 257628-95-8
9-hydroxy-5-(3,4,5-trimethoxy-phenyl)-7,8,8a,9-tetrahydro-5H-1,3-dioxa-5a-aza-dicyclopenta[b,g]naphthalen-6-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: triflic acid / CH₂Cl₂ / 130 °C

1.2: 30 percent / trifluoroacetic acid; boron trifluoride etherate / 1,2-dichloro-ethane / 7 h / Heating

2.1: 92 percent / lithium tri-tert-butoxyaluminohydride / tetrahydrofuran / 2 h / 20 °C

With lithium tri(t-butoxy)aluminum hydride; trifluorormethanesulfonic acid; In tetrahydrofuran; dichloromethane; 1.1: Condensation / 1.2: Cyclization / 2.1: Hydrogenation;
DOI:10.1002/jhet.5570360525

Reference yield:

: (R)-1-[Benzo[1,3]dioxol-5-yl-(3,4,5-trimethoxy-phenyl)-methyl]-5-oxo-pyrrolidine-2-carboxylic acid

: 257628-95-8
9-hydroxy-5-(3,4,5-trimethoxy-phenyl)-7,8,8a,9-tetrahydro-5H-1,3-dioxa-5a-aza-dicyclopenta[b,g]naphthalen-6-one

Guidance literature:: Multi-step reaction with 2 steps

1: 32 percent / trifluoroacetic anhydride; boron trifluoride etherate / 1,2-dichloro-ethane / 7 h / Heating

2: 92 percent / lithium tri-tert-butoxyaluminohydride / tetrahydrofuran / 2 h / 20 °C

With lithium tri(t-butoxy)aluminum hydride; boron trifluoride diethyl etherate; trifluoroacetic anhydride; In tetrahydrofuran; 1,2-dichloro-ethane; 1: Cyclization / 2: Hydrogenation;
DOI:10.1002/jhet.5570360525