N-isopentyl-3-[4-(4-Methoxyphenylamino)-2-oxo-2H-pyridin-1-yl]propionamide

Base Information

• Chemical Name: N-isopentyl-3-[4-(4-Methoxyphenylamino)-2-oxo-2H-pyridin-1-yl]propionamide
• CAS No.: 1624283-54-0
• Molecular Formula: C₂₀H₂₇N₃O₃
• Molecular Weight: 357.453

Synonyms:N-isopentyl-3-[4-(4-Methoxyphenylamino)-2-oxo-2H-pyridin-1-yl]propionamide

Chemical Property of N-isopentyl-3-[4-(4-Methoxyphenylamino)-2-oxo-2H-pyridin-1-yl]propionamide

Chemical Property:

Purity/Quality:

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Technology Process of N-isopentyl-3-[4-(4-Methoxyphenylamino)-2-oxo-2H-pyridin-1-yl]propionamide

There total 11 articles about N-isopentyl-3-[4-(4-Methoxyphenylamino)-2-oxo-2H-pyridin-1-yl]propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(aR,3aS,4S,6S,7aR)-hexahydro-3a,8,8-trimethyl-α-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate (1310383-72-2,179324-87-9) + 3-[4-(4-methoxyphenylamino)-2-oxopyridin-1(2H)-yl]propanoic acid (1624283-83-5) → (R)-1-{3-[4-(4-methoxyphenylamino)-2-oxopyridin-1(2H)-yl]propanamido}-3-methylbutylboronic acid pinanediol ester (1624283-97-1) + N-isopentyl-3-[4-(4-Methoxyphenylamino)-2-oxo-2H-pyridin-1-yl]propionamide (1624283-54-0)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -15 - 20 ℃; for 3h;

DOI:10.1002/cmdc.201402075

Reference yield:

(aR,3aS,4S,6S,7aR)-hexahydro-3a,8,8-trimethyl-α-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate (1310383-72-2,179324-87-9) + 3-[4-(4-methoxyphenylamino)-2-oxopyridin-1(2H)-yl]propanoic acid (1624283-83-5) → N-isopentyl-3-[4-(4-Methoxyphenylamino)-2-oxo-2H-pyridin-1-yl]propionamide (1624283-54-0)

Guidance literature:

With hydrogenchloride; Dihydroxy-isobutyl-boran; In methanol; hexane; water; at 20 ℃; for 18h;

DOI:10.1002/cmdc.201402075

Reference yield:

methyl 3-[4-(4-methoxyphenylamino)-2-oxopyridin-1(2H)-yl]propanoate (1624283-70-0) → N-isopentyl-3-[4-(4-Methoxyphenylamino)-2-oxo-2H-pyridin-1-yl]propionamide (1624283-54-0)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium hydroxide / methanol; water / 4 h / 0 - 20 °C

2: hydrogenchloride; Dihydroxy-isobutyl-boran / methanol; hexane; water / 18 h / 20 °C

With hydrogenchloride; Dihydroxy-isobutyl-boran; lithium hydroxide; In methanol; hexane; water;

DOI:10.1002/cmdc.201402075

upstream raw materials:

(aR,3aS,4S,6S,7aR)-hexahydro-3a,8,8-trimethyl-α-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate

3-[4-(4-methoxyphenylamino)-2-oxopyridin-1(2H)-yl]propanoic acid

methyl 3-[4-(4-methoxyphenylamino)-2-oxopyridin-1(2H)-yl]propanoate

2-(Benzyloxy)-N-(4-methoxyphenyl)pyridin-4-amine

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