(3'aR-(3'aα,6'aα))-3',3'a,4',6'a-tetrahydro-5'-[5-(1-ethoxyethoxy)pentyl]spiro[5,5-dimethyl-1,3-dioxan-2,2'-(1'H)-pentalen]

Base Information

Chemical Name:(3'aR-(3'aα,6'aα))-3',3'a,4',6'a-tetrahydro-5'-[5-(1-ethoxyethoxy)pentyl]spiro[5,5-dimethyl-1,3-dioxan-2,2'-(1'H)-pentalen]
CAS No.:210296-01-8
Molecular Formula:C₂₂H₃₈O₄
Molecular Weight:366.541
Hs Code.:

Synonyms:(3'aR-(3'aα,6'aα))-3',3'a,4',6'a-tetrahydro-5'-[5-(1-ethoxyethoxy)pentyl]spiro[5,5-dimethyl-1,3-dioxan-2,2'-(1'H)-pentalen]

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3'aR-(3'aα,6'aα))-3',3'a,4',6'a-tetrahydro-5'-[5-(1-ethoxyethoxy)pentyl]spiro[5,5-dimethyl-1,3-dioxan-2,2'-(1'H)-pentalen]

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Technology Process of (3'aR-(3'aα,6'aα))-3',3'a,4',6'a-tetrahydro-5'-[5-(1-ethoxyethoxy)pentyl]spiro[5,5-dimethyl-1,3-dioxan-2,2'-(1'H)-pentalen]

There total 1 articles about (3'aR-(3'aα,6'aα))-3',3'a,4',6'a-tetrahydro-5'-[5-(1-ethoxyethoxy)pentyl]spiro[5,5-dimethyl-1,3-dioxan-2,2'-(1'H)-pentalen] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: C₁₆H₃₄CuO₄^(1-)*Li⁽¹⁺⁾

: 143962-63-4
[3'aR-(3'aα,5'(R^*),6'aα)]-N-methyl-S-phenyl-S-{[3',3'a,4',6'a-tetrahydro-5,5-dimethylspiro(1,3-dioxan-2,2'(1'H)-pentalen)-5'-yl]methyl}sulfoximine

: 33957-73-2,69726-27-8,84413-63-8,33993-55-4
Benzenesulfinic acid (R)-methylamide

: 210296-01-8
(3'aR-(3'aα,6'aα))-3',3'a,4',6'a-tetrahydro-5'-[5-(1-ethoxyethoxy)pentyl]spiro[5,5-dimethyl-1,3-dioxan-2,2'-(1'H)-pentalen]

Guidance literature:: With dimethylsulfide; In diethyl ether; at -45 ℃; for 6h;

Reference yield:

: 210296-01-8
(3'aR-(3'aα,6'aα))-3',3'a,4',6'a-tetrahydro-5'-[5-(1-ethoxyethoxy)pentyl]spiro[5,5-dimethyl-1,3-dioxan-2,2'-(1'H)-pentalen]

: (E)-1-{(1R,2R,3aS,6aS)-5-[5-(tert-Butyl-diphenyl-silanyloxy)-pentyl]-2-hydroxy-1,2,3,3a,6,6a-hexahydro-pentalen-1-yl}-oct-1-en-3-one

Guidance literature:: Multi-step reaction with 8 steps

1: 77 percent / p-TsOH / acetone; H₂O / 24 h / Ambient temperature

2: 80 percent / imidazole / dimethylformamide / 0.67 h / 0 °C

3: 1.) (R,R)-bis(α-phenylethyl)ammonium chloride, n-BuLi / 1.) THF, hexane, -72 deg C, 10 min, then -100 deg C, 2 h; 2.) THF, hexane, -108 - -104 deg C, 35 min, then -70 deg C, 3 h

4: 88 percent / NaBH₄ / ethanol / 7 h / -40 °C / 1.) -66 deg C

5: 98 percent / pyridine / tetrahydrofuran / 23 h / Ambient temperature

6: Pd(MeCN)2Cl₂ / tetrahydrofuran / 17 h / Ambient temperature

7: 94 percent / K₂CO₃ / methanol / 4 h / Ambient temperature

8: 81 percent / dichlorodicyanobenzoquinone / dioxane / 22 h / Ambient temperature

With pyridine; 1H-imidazole; dichloro bis(acetonitrile) palladium(II); sodium tetrahydroborate; n-butyllithium; (R,R)-(+)-bis[alpha-methylbenzyl]amine hydrochloride; potassium carbonate; toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 210296-01-8
(3'aR-(3'aα,6'aα))-3',3'a,4',6'a-tetrahydro-5'-[5-(1-ethoxyethoxy)pentyl]spiro[5,5-dimethyl-1,3-dioxan-2,2'-(1'H)-pentalen]

: tert-Butyl-{5-[(4S,4aR,4bS,7aS,8aR)-4-((E)-hept-1-enyl)-2,2-dimethyl-4a,4b,5,7a,8,8a-hexahydro-4H-pentaleno[2,1-d][1,3]dioxin-6-yl]-pentyloxy}-diphenyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / p-TsOH / acetone; H₂O / 24 h / Ambient temperature

2: 80 percent / imidazole / dimethylformamide / 0.67 h / 0 °C

3: 1.) (R,R)-bis(α-phenylethyl)ammonium chloride, n-BuLi / 1.) THF, hexane, -72 deg C, 10 min, then -100 deg C, 2 h; 2.) THF, hexane, -108 - -104 deg C, 35 min, then -70 deg C, 3 h

4: 84 percent / NaBH₄ / ethanol / 5 h / -50 °C / 1.) -66 deg C

5: 87 percent / ω-camphorsulfonic acid / acetone / 0.25 h / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; n-butyllithium; (1S)-10-camphorsulfonic acid; (R,R)-(+)-bis[alpha-methylbenzyl]amine hydrochloride; toluene-4-sulfonic acid; In ethanol; water; N,N-dimethyl-formamide; acetone;