Technology Process of Anamorelin
There total 9 articles about Anamorelin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(R,R)-{1-[2-[3-benzyl-3-(N,N',N'-trimethyl-hydrazinocarbonyl)piperidin-1-yl]-1-(1H-indol-3-ylmethyl)-2-oxo-ethylcarbamoyl]-1-methylethyl}carbamic acid tert-butyl ester;
With
methanol; methanesulfonic acid;
at 50 - 70 ℃;
for 0.75h;
With
potassium hydroxide;
In
methanol; water;
at 22 - 70 ℃;
for 43h;
In
water;
at 50 ℃;
for 41h;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 38 °C
2.1: 3-hydroxy-3,4-dihydrobenzotriazine-4-one; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C
2.2: 20 °C
3.1: hydrogenchloride / ethyl acetate
With
hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one;
In
dichloromethane; ethyl acetate;
DOI:10.1021/op0502506
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydroxide / water; tert-butyl methyl ether / 20 °C / Large scale
2.1: 3-hydroxy-3,4-dihydrobenzotriazine-4-one; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C
2.2: 20 °C
3.1: hydrogenchloride / ethyl acetate
With
hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; sodium hydroxide;
In
dichloromethane; tert-butyl methyl ether; water; ethyl acetate;
DOI:10.1021/op0502506
