2-(tert-butyl-diphenyl-silanyloxymethyl)-5-[5-(2-methyl-[1,3]dioxolan-2-yl)-pentyl]-3,4-dihydro-2H-pyrrole

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Chemical Name:2-(tert-butyl-diphenyl-silanyloxymethyl)-5-[5-(2-methyl-[1,3]dioxolan-2-yl)-pentyl]-3,4-dihydro-2H-pyrrole
CAS No.:852674-73-8
Molecular Formula:C₃₀H₄₃NO₃Si
Molecular Weight:493.762
Hs Code.:

2-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-5-[5-(2-methyl-[1,3]dioxolan-2-yl)-pentyl]-3,4-dihydro-2<i>H</i>-pyrrole

Synonyms:2-(tert-butyl-diphenyl-silanyloxymethyl)-5-[5-(2-methyl-[1,3]dioxolan-2-yl)-pentyl]-3,4-dihydro-2H-pyrrole

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Chemical Property of 2-(tert-butyl-diphenyl-silanyloxymethyl)-5-[5-(2-methyl-[1,3]dioxolan-2-yl)-pentyl]-3,4-dihydro-2H-pyrrole

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Technology Process of 2-(tert-butyl-diphenyl-silanyloxymethyl)-5-[5-(2-methyl-[1,3]dioxolan-2-yl)-pentyl]-3,4-dihydro-2H-pyrrole

There total 2 articles about 2-(tert-butyl-diphenyl-silanyloxymethyl)-5-[5-(2-methyl-[1,3]dioxolan-2-yl)-pentyl]-3,4-dihydro-2H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 852674-72-7
(S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-1-((E)-hept-1-enyl)-pyrrolidin-2-one

: 121407-72-5
2-(5-iodopentyl)-2-methyl-1,3-dioxolane

: 852674-73-8
2-(tert-butyl-diphenyl-silanyloxymethyl)-5-[5-(2-methyl-[1,3]dioxolan-2-yl)-pentyl]-3,4-dihydro-2H-pyrrole

Guidance literature:: 2-(5-iodopentyl)-2-methyl-1,3-dioxolane; With tert.-butyl lithium; In diethyl ether; at -78 ℃; for 2h;

(S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-1-((E)-hept-1-enyl)-pyrrolidin-2-one; In tetrahydrofuran; diethyl ether; at -78 ℃; for 5h;
DOI:10.1021/jo0501846

Reference yield:

: 132974-83-5
(5S)-5-[[(tert-butyldiphenylsilyl)oxy]methyl]pyrrolidin-2-one

: 852674-73-8
2-(tert-butyl-diphenyl-silanyloxymethyl)-5-[5-(2-methyl-[1,3]dioxolan-2-yl)-pentyl]-3,4-dihydro-2H-pyrrole

Guidance literature:: Multi-step reaction with 2 steps

1.1: 62 percent / P₂O₅ / toluene / 12 h / Heating

2.1: t-BuLi / diethyl ether / 2 h / -78 °C

2.2: 55 percent / diethyl ether; tetrahydrofuran / 5 h / -78 °C

With tert.-butyl lithium; phosphorus pentoxide; In diethyl ether; toluene;
DOI:10.1021/jo0501846