1-benzyl 5-[2-(diphenylphosphanyl)-4-fluorophenyl]-N-(benzyloxycarbonyl)-L-glutamate

Base Information

Chemical Name:1-benzyl 5-[2-(diphenylphosphanyl)-4-fluorophenyl]-N-(benzyloxycarbonyl)-L-glutamate
CAS No.:1461715-83-2
Molecular Formula:C₃₈H₃₃FNO₆P
Molecular Weight:649.655
Hs Code.:

Synonyms:1-benzyl 5-[2-(diphenylphosphanyl)-4-fluorophenyl]-N-(benzyloxycarbonyl)-L-glutamate

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Chemical Property of 1-benzyl 5-[2-(diphenylphosphanyl)-4-fluorophenyl]-N-(benzyloxycarbonyl)-L-glutamate

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Technology Process of 1-benzyl 5-[2-(diphenylphosphanyl)-4-fluorophenyl]-N-(benzyloxycarbonyl)-L-glutamate

There total 1 articles about 1-benzyl 5-[2-(diphenylphosphanyl)-4-fluorophenyl]-N-(benzyloxycarbonyl)-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 3705-42-8
Cbz-(L)-Glu-OBn

: 2-(diphenylphosphanyl)-4-fluorophenol

: 1461715-83-2
1-benzyl 5-[2-(diphenylphosphanyl)-4-fluorophenyl]-N-(benzyloxycarbonyl)-L-glutamate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.3390/molecules18088779

Reference yield: 76.0%

: 1220340-25-9
5-tert-butyldiphenylsilyl-β-D-ribofuranosyl azide

: 1461715-83-2
1-benzyl 5-[2-(diphenylphosphanyl)-4-fluorophenyl]-N-(benzyloxycarbonyl)-L-glutamate

: 1461715-85-4
N^δ-(5-tert-butyldiphenylsilyl-α-D-ribosyl)-N^α-benzyloxycarbonylglutamine benzyl ester

Guidance literature:: 5-tert-butyldiphenylsilyl-β-D-ribofuranosyl azide; 1-benzyl 5-[2-(diphenylphosphanyl)-4-fluorophenyl]-N-(benzyloxycarbonyl)-L-glutamate; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; N,N-dimethyl acetamide; at 20 - 70 ℃; for 20h;

With water; at 70 ℃; for 2h; stereoselective reaction;
DOI:10.3390/molecules18088779

Reference yield:

: 51970-31-1
(2R,3R,4S,5R)-2-azido-5-hydroxymethyl-tetrahydro-furan-3,4-diol

: 1461715-83-2
1-benzyl 5-[2-(diphenylphosphanyl)-4-fluorophenyl]-N-(benzyloxycarbonyl)-L-glutamate

: 1461715-88-7
C₂₅H₃₀N₂O₉

: 1461715-91-2
C₂₅H₃₀N₂O₉

Guidance literature:: (2R,3R,4S,5R)-2-azido-5-hydroxymethyl-tetrahydro-furan-3,4-diol; 1-benzyl 5-[2-(diphenylphosphanyl)-4-fluorophenyl]-N-(benzyloxycarbonyl)-L-glutamate; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; N,N-dimethyl acetamide; at 20 - 70 ℃; for 20h;

With water; at 70 ℃; for 2h;
DOI:10.3390/molecules18088779