N-[4-(2-N-benzylcarbamylethoxy-4,6-dihydroxyphenyl)]-2'-deoxy-5-bromouridine

Base Information

Chemical Name:N-[4-(2-N-benzylcarbamylethoxy-4,6-dihydroxyphenyl)]-2'-deoxy-5-bromouridine
CAS No.:1332507-67-1
Molecular Formula:C₂₅H₂₇BrN₄O₉
Molecular Weight:607.415
Hs Code.:

Synonyms:N-[4-(2-N-benzylcarbamylethoxy-4,6-dihydroxyphenyl)]-2'-deoxy-5-bromouridine

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Chemical Property of N-[4-(2-N-benzylcarbamylethoxy-4,6-dihydroxyphenyl)]-2'-deoxy-5-bromouridine

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Technology Process of N-[4-(2-N-benzylcarbamylethoxy-4,6-dihydroxyphenyl)]-2'-deoxy-5-bromouridine

There total 8 articles about N-[4-(2-N-benzylcarbamylethoxy-4,6-dihydroxyphenyl)]-2'-deoxy-5-bromouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1332507-65-9
3',5'-di-O-acetyl-N-[4-(2-N-benzylcarbamyl-ethoxy-6-hydroxy-4-O-pivaloylphenyl)]-2'-deoxy-5-bromouridine

: 1332507-67-1
N-[4-(2-N-benzylcarbamylethoxy-4,6-dihydroxyphenyl)]-2'-deoxy-5-bromouridine

: 1332507-66-0
N-[4-(2-N-benzylcarbamylethoxy-6-hydroxy-4-O-pivaloylphenyl)]-2'-deoxy-5-bromouridine

Guidance literature:: 3',5'-di-O-acetyl-N-[4-(2-N-benzylcarbamyl-ethoxy-6-hydroxy-4-O-pivaloylphenyl)]-2'-deoxy-5-bromouridine; With potassium carbonate; In methanol; at 20 ℃; for 0.5h;

With water; In methanol;
DOI:10.1016/j.tet.2011.03.111

Reference yield:

: 1332507-68-2
4-O-pivaloyl-2-aminophloroglucinol

: 1332507-67-1
N-[4-(2-N-benzylcarbamylethoxy-4,6-dihydroxyphenyl)]-2'-deoxy-5-bromouridine

Guidance literature:: Multi-step reaction with 3 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 12 h / 20 °C / Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 24 h / 20 °C / Inert atmosphere

3: potassium carbonate / methanol / 0.5 h / 20 °C

With di-isopropyl azodicarboxylate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In methanol; dichloromethane; 2: Mitsunobu reaction;
DOI:10.1016/j.tet.2011.03.111

Reference yield:

: C₁₁H₁₃NO₆

: 1332507-67-1
N-[4-(2-N-benzylcarbamylethoxy-4,6-dihydroxyphenyl)]-2'-deoxy-5-bromouridine

Guidance literature:: Multi-step reaction with 4 steps

1: 5%-palladium/activated carbon; hydrogen / methanol / 2.5 h / 0 - 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 12 h / 20 °C / Inert atmosphere

3: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 24 h / 20 °C / Inert atmosphere

4: potassium carbonate / methanol / 0.5 h / 20 °C

With di-isopropyl azodicarboxylate; 5%-palladium/activated carbon; hydrogen; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In methanol; dichloromethane; 3: Mitsunobu reaction;
DOI:10.1016/j.tet.2011.03.111