Palovarotene

Base Information

Chemical Name:Palovarotene
CAS No.:410528-02-8
Molecular Formula:C₂₇H₃₀N₂O₂
Molecular Weight:414.547
Hs Code.:
UNII:28K6I5M16G
DSSTox Substance ID:DTXSID301025696
Wikipedia:Palovarotene
Wikidata:Q15708269
NCI Thesaurus Code:C80661
Metabolomics Workbench ID:153331
ChEMBL ID:CHEMBL2105648
Mol file:410528-02-8.mol

Synonyms:Palovarotene;R-667;RG-667;RO-3300074

Suppliers and Price of Palovarotene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Palovarotene
100mg
$ 1455.00

Medical Isotopes, Inc.
Palovarotene
100 mg
$ 2200.00

DC Chemicals
Palovarotene(R667) >98%
250 mg
$ 880.00

DC Chemicals
Palovarotene(R667) >98%
1 g
$ 1700.00

Crysdot
Palovarotene 98+%
100mg
$ 1237.00

Crysdot
Palovarotene 98+%
10mg
$ 402.00

Crysdot
Palovarotene 98+%
5mg
$ 217.00

ChemScene
Palovarotene 99.49%
5mg
$ 160.00

ChemScene
Palovarotene 99.49%
100mg
$ 1600.00

ChemScene
Palovarotene 99.49%
50mg
$ 950.00

Total 32 raw suppliers

Chemical Property of Palovarotene

Chemical Property:

Boiling Point:592.3±50.0 °C(Predicted)
PKA:4.26±0.10(Predicted)
PSA：55.12000
Density:1.11g/cm³
LogP:6.14900
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly, Heated)
XLogP3:6.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:414.230728204
Heavy Atom Count:31
Complexity:662

Purity/Quality:

99%, ^*data from raw suppliers

Palovarotene ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(CCC(C2=C1C=C(C(=C2)C=CC3=CC=C(C=C3)C(=O)O)CN4C=CC=N4)(C)C)C
Isomeric SMILES:CC1(CCC(C2=C1C=C(C(=C2)/C=C/C3=CC=C(C=C3)C(=O)O)CN4C=CC=N4)(C)C)C
Recent ClinicalTrials:A Rollover Study to Further Evaluate the Safety and Efficacy of Palovarotene Capsules in Male and Female Participants Aged ≥14 Years With Fibrodysplasia Ossificans Progressiva (FOP) Who Have Completed the Relevant Parent Studies.
Recent EU Clinical Trials:A Phase 2, Open-Label, Efficacy and Safety Study of an RARγ-Specific Agonist (Palovarotene) to Prevent Heterotopic Ossification in Subjects with Fibrodysplasia Ossificans Progressiva (FOP)
Description Palovarotene an orally bioavailable retinoic acid receptor γ (RARγ) agonist. It increases retinoic acid response element (RARE) activity and decreases NF-κB activity induced by IL-1β in primary mouse stromal cells in reporter assays when used at a concentration of 60 nM. Palovarotene (10 nM) inhibits activin A-induced chondrogenic and osteogenic differentiation of mouse fibro/adipogenic progenitors (FAPs) expressing a mutated form of human activin A receptor type I (ACVR1R206H). It inhibits heterotopic ossification and preserves limb movement and growth in a ACVR1R206H fibrodysplasia ossificans progressiva (FOP) mouse model. Palovarotene (1 mg/kg per day for 14 days) decreases heterotopic ossification by 50 to 60% in a rat model of traumatic blast injury.
Uses Palovarotene, is a highly selective retinoic acid receptor gamma (RAR-γ) agonist that is under investigation as a potential treatment for emphysema.

Technology Process of Palovarotene

There total 2 articles about Palovarotene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₃₄N₂O₂

: 410528-02-8
Palovarotene

Guidance literature:: C₂₉H₃₄N₂O₂; With sodium hydroxide; water; In ethanol; for 14h; Heating / reflux;

With sulfuric acid; In ethanol; water;