Melogliptin

Base Information

Chemical Name:Melogliptin
CAS No.:868771-57-7
Molecular Formula:C15H21 F N6 O
Molecular Weight:320.37
Hs Code.:
UNII:I3N8016NKU
NCI Thesaurus Code:C87620
Wikidata:Q27280336
Mol file:868771-57-7.mol

Synonyms:Melogliptin;868771-57-7;Melogliptin [INN];UNII-I3N8016NKU;I3N8016NKU;GRC 8200;(2S,4S)-4-fluoro-1-[2-[[(1R,3S)-3-(1,2,4-triazol-1-ylmethyl)cyclopentyl]amino]acetyl]pyrrolidine-2-carbonitrile;GRC8200;MELOGLIPTIN [WHO-DD];SCHEMBL195916;JSYGLDMGERSRPC-FQUUOJAGSA-N;Q27280336;(2S,4S)-1-{2-[(3S,1R)-3-(1H-1,2,4-Triazol-1-ylmethyl)cyclopentyl-amino]acetyl}-4-fluoropyrrolidine-2-carbonitrile;(2s,4s)-1-{2-[(3s,1r)-3-(1h-1,2,4-triazol-1-ylmethyl)cyclopentylamino]acetyl}-4-fluoropyrrolidine-2-carbonitrile;(2S,4S)-4-FLUORO-1-(2-(((1R,3S)-3-((1H-1,2,4-TRIAZOL-1-YL)METHYL)CYCLOPENTYL)AMINO)ACETYL)PYRROLIDINE-2-CARBONITRILE

Suppliers and Price of Melogliptin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
MELOGLIPTIN 95.00%
5MG
$ 501.59

Total 10 raw suppliers

Chemical Property of Melogliptin

Chemical Property:

PSA：86.84000
Density:1.44
LogP:0.82778
XLogP3:0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:320.17608748
Heavy Atom Count:23
Complexity:480

Purity/Quality:

98%Min ^*data from raw suppliers

MELOGLIPTIN 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(CC1CN2C=NC=N2)NCC(=O)N3CC(CC3C#N)F
Isomeric SMILES:C1C[C@H](C[C@H]1CN2C=NC=N2)NCC(=O)N3C[C@H](C[C@H]3C#N)F
Recent ClinicalTrials:A Clinical Study of GRC 8200 in Type 2 Diabetes Mellitus

Technology Process of Melogliptin

There total 2 articles about Melogliptin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1000616-36-3
(2S,4S)-1-{2-[(3S,1R)-3-(1H-1,2,4-triazol-1-ylmethyl)cyclopentyl-N-BOC-amino]acetyl}-4-fluoropyrrolidine-2-carboxamide

: 868771-57-7
Melogliptin

Guidance literature:: (2S,4S)-1-{2-[(3S,1R)-3-(1H-1,2,4-triazol-1-ylmethyl)cyclopentyl-N-BOC-amino]acetyl}-4-fluoropyrrolidine-2-carboxamide; With hydrogenchloride; In ethyl acetate; at 10 ℃; for 1h;

With water; potassium carbonate; pH=13;