5-(benzyloxy)-N-(2-(tert-butyldimethylsilyloxy)ethyl)-6-hydroxy-N-isopropyl-2-(2-methyl-2-phenylpropyl)pyrimidine-4-carboxamide

Base Information

Chemical Name:5-(benzyloxy)-N-(2-(tert-butyldimethylsilyloxy)ethyl)-6-hydroxy-N-isopropyl-2-(2-methyl-2-phenylpropyl)pyrimidine-4-carboxamide
CAS No.:1616923-08-0
Molecular Formula:C₃₃H₄₇N₃O₄Si
Molecular Weight:577.839
Hs Code.:

Synonyms:5-(benzyloxy)-N-(2-(tert-butyldimethylsilyloxy)ethyl)-6-hydroxy-N-isopropyl-2-(2-methyl-2-phenylpropyl)pyrimidine-4-carboxamide

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Chemical Property of 5-(benzyloxy)-N-(2-(tert-butyldimethylsilyloxy)ethyl)-6-hydroxy-N-isopropyl-2-(2-methyl-2-phenylpropyl)pyrimidine-4-carboxamide

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Technology Process of 5-(benzyloxy)-N-(2-(tert-butyldimethylsilyloxy)ethyl)-6-hydroxy-N-isopropyl-2-(2-methyl-2-phenylpropyl)pyrimidine-4-carboxamide

There total 10 articles about 5-(benzyloxy)-N-(2-(tert-butyldimethylsilyloxy)ethyl)-6-hydroxy-N-isopropyl-2-(2-methyl-2-phenylpropyl)pyrimidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: N-(2-((tert-butyldimethylsilyl)oxy)ethyl)propan-2-amine

: 1616923-07-9
5-(benzyloxy)-6-hydroxy-2-(2-methyl-2-phenylpropyl)pyrimidine-4-carboxylic acid

: 1616923-08-0
5-(benzyloxy)-N-(2-(tert-butyldimethylsilyloxy)ethyl)-6-hydroxy-N-isopropyl-2-(2-methyl-2-phenylpropyl)pyrimidine-4-carboxamide

Guidance literature:: With pyridine; trichlorophosphate; at -10 - 0 ℃; for 2h;

Reference yield:

: 30379-55-6
benzyloxyacetic acid

: 1616923-08-0
5-(benzyloxy)-N-(2-(tert-butyldimethylsilyloxy)ethyl)-6-hydroxy-N-isopropyl-2-(2-methyl-2-phenylpropyl)pyrimidine-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / 3 h / 0 - 20 °C

2: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 2 h / -78 - 20 °C

3: sodium methylate / methanol / 0 - 20 °C

4: lithium hydroxide monohydrate / tetrahydrofuran; water / 7 h / 85 °C

5: pyridine; trichlorophosphate / 2 h / -10 - 0 °C

With pyridine; n-butyllithium; thionyl chloride; lithium hydroxide monohydrate; sodium methylate; diisopropylamine; trichlorophosphate; In tetrahydrofuran; methanol; hexane; water;

Reference yield:

: 31600-43-8
methyl 2-(benzyloxy)acetate

: 1616923-08-0
5-(benzyloxy)-N-(2-(tert-butyldimethylsilyloxy)ethyl)-6-hydroxy-N-isopropyl-2-(2-methyl-2-phenylpropyl)pyrimidine-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 2 h / -78 - 20 °C

2: sodium methylate / methanol / 0 - 20 °C

3: lithium hydroxide monohydrate / tetrahydrofuran; water / 7 h / 85 °C

4: pyridine; trichlorophosphate / 2 h / -10 - 0 °C

With pyridine; n-butyllithium; lithium hydroxide monohydrate; sodium methylate; diisopropylamine; trichlorophosphate; In tetrahydrofuran; methanol; hexane; water;