6-Chloro-3-(2-hydroxy-ethyl)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol; hydrobromide

Base Information

Chemical Name:6-Chloro-3-(2-hydroxy-ethyl)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol; hydrobromide
CAS No.:80751-90-2
Molecular Formula:BrH*C₁₈H₂₀ClNO₃
Molecular Weight:414.727
Hs Code.:

Synonyms:6-Chloro-3-(2-hydroxy-ethyl)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol; hydrobromide

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Chemical Property of 6-Chloro-3-(2-hydroxy-ethyl)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol; hydrobromide

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Technology Process of 6-Chloro-3-(2-hydroxy-ethyl)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol; hydrobromide

There total 3 articles about 6-Chloro-3-(2-hydroxy-ethyl)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol; hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(6-Chloro-7,8-dimethoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-ethanol

: 80751-90-2
6-Chloro-3-(2-hydroxy-ethyl)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol; hydrobromide

Guidance literature:: With boron tribromide; In dichloromethane; at 25 ℃; for 18h;
DOI:10.1021/jm00346a005

Reference yield:

: 67287-37-0
N-(2-Hydroxy-2-phenethyl)-N-<2-(2'-chlor-3',4'-dimethoxyphenyl)-ethyl>-amin

: 80751-90-2
6-Chloro-3-(2-hydroxy-ethyl)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol; hydrobromide

Guidance literature:: Multi-step reaction with 3 steps

1: H₂SO₄, CF₃COOH / 2 h / Heating

2: 88 percent / K₂CO₃ / dimethylformamide / 8 h / 145 °C

3: BBr₃ / CH₂Cl₂ / 18 h / 25 °C

With sulfuric acid; boron tribromide; potassium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00346a005

Reference yield:

: 67287-38-1
6-chloro-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

: 80751-90-2
6-Chloro-3-(2-hydroxy-ethyl)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol; hydrobromide

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / K₂CO₃ / dimethylformamide / 8 h / 145 °C

2: BBr₃ / CH₂Cl₂ / 18 h / 25 °C

With boron tribromide; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00346a005