2,2,2-Trifluoro-N-[(2S,3R,5R)-5-hydroxy-2-(1-hydroxy-1-methyl-ethyl)-tetrahydro-furan-3-yl]-acetamide

Base Information

Chemical Name:2,2,2-Trifluoro-N-[(2S,3R,5R)-5-hydroxy-2-(1-hydroxy-1-methyl-ethyl)-tetrahydro-furan-3-yl]-acetamide
CAS No.:82010-49-9
Molecular Formula:C₉H₁₄F₃NO₄
Molecular Weight:257.21
Hs Code.:

Synonyms:2,2,2-Trifluoro-N-[(2S,3R,5R)-5-hydroxy-2-(1-hydroxy-1-methyl-ethyl)-tetrahydro-furan-3-yl]-acetamide

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Chemical Property of 2,2,2-Trifluoro-N-[(2S,3R,5R)-5-hydroxy-2-(1-hydroxy-1-methyl-ethyl)-tetrahydro-furan-3-yl]-acetamide

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Technology Process of 2,2,2-Trifluoro-N-[(2S,3R,5R)-5-hydroxy-2-(1-hydroxy-1-methyl-ethyl)-tetrahydro-furan-3-yl]-acetamide

There total 1 articles about 2,2,2-Trifluoro-N-[(2S,3R,5R)-5-hydroxy-2-(1-hydroxy-1-methyl-ethyl)-tetrahydro-furan-3-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1756-18-9
(2RS)-2,3-dihydroxy-3-methylbutanoic acid

: 82010-49-9
2,2,2-Trifluoro-N-[(2S,3R,5R)-5-hydroxy-2-(1-hydroxy-1-methyl-ethyl)-tetrahydro-furan-3-yl]-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: HCl(g) / 16 h / Ambient temperature

2: 4-toluenesulfonic acid / benzene / Heating

3: 82 percent / LiAlH₄ / diethyl ether / 3 h

4: 1.) pyridinium chlorchromate, 2.) benzoic acid / 1.) CH₂Cl₂, room temp., 3 h, 2.) diethyl ether, reflux, 4 h

5: NH₃ / 120 h / Ambient temperature

6: 1.) 2 N HCl / 1.) ether, reflux, 2 h, 2.) CH₂Cl₂, room temp., overnight

7: diisobutylaluminum hydride / tetrahydrofuran; toluene / 4 h / -40 °C

With hydrogenchloride; lithium aluminium tetrahydride; pyridinium chlorchromate; ammonia; diisobutylaluminium hydride; toluene-4-sulfonic acid; benzoic acid; In tetrahydrofuran; diethyl ether; toluene; benzene;
DOI:10.1021/jo00138a018