4-<<6-<(2-ethylbutyl)carbamoyl>-3-methylindol-1-yl>methyl>-3-methoxybenzoic acid

Base Information

Chemical Name:4-<<6-<(2-ethylbutyl)carbamoyl>-3-methylindol-1-yl>methyl>-3-methoxybenzoic acid
CAS No.:145889-38-9
Molecular Formula:C₂₅H₃₀N₂O₄
Molecular Weight:422.524
Hs Code.:

Synonyms:4-<<6-<(2-ethylbutyl)carbamoyl>-3-methylindol-1-yl>methyl>-3-methoxybenzoic acid

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Chemical Property of 4-<<6-<(2-ethylbutyl)carbamoyl>-3-methylindol-1-yl>methyl>-3-methoxybenzoic acid

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Technology Process of 4-<<6-<(2-ethylbutyl)carbamoyl>-3-methylindol-1-yl>methyl>-3-methoxybenzoic acid

There total 6 articles about 4-<<6-<(2-ethylbutyl)carbamoyl>-3-methylindol-1-yl>methyl>-3-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 70264-94-7
methyl 4-(bromomethyl)-3-methoxybenzoate

: 145889-38-9
4-<<6-<(2-ethylbutyl)carbamoyl>-3-methylindol-1-yl>methyl>-3-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / K₂CO₃ / dimethylformamide / 18 h / Ambient temperature

2: NaBH₄ / ethanol / 0.02 h / Heating

3: Et₃N / CH₂Cl₂ / 18 h / Ambient temperature

4: H₂ / 5percent Pd/C / ethyl acetate / 18 h / 2585.7 Torr

5: aq. LiOH / tetrahydrofuran; methanol / 18 h / Ambient temperature

With lithium hydroxide; sodium tetrahydroborate; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00055a011

Reference yield:

: 145889-35-6
6-<(2-ethylbutyl)carbamoyl>-3-formylindole

: 145889-38-9
4-<<6-<(2-ethylbutyl)carbamoyl>-3-methylindol-1-yl>methyl>-3-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / K₂CO₃ / dimethylformamide / 18 h / Ambient temperature

2: NaBH₄ / ethanol / 0.02 h / Heating

3: Et₃N / CH₂Cl₂ / 18 h / Ambient temperature

4: H₂ / 5percent Pd/C / ethyl acetate / 18 h / 2585.7 Torr

5: aq. LiOH / tetrahydrofuran; methanol / 18 h / Ambient temperature

With lithium hydroxide; sodium tetrahydroborate; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00055a011

Reference yield:

: 145889-36-7
methyl 4-<<6-<(2-ethylbutyl)carbamoyl>-3-formylindol-1-yl>methyl>-3-methoxybenzoate

: 145889-38-9
4-<<6-<(2-ethylbutyl)carbamoyl>-3-methylindol-1-yl>methyl>-3-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: NaBH₄ / ethanol / 0.02 h / Heating

2: Et₃N / CH₂Cl₂ / 18 h / Ambient temperature

3: H₂ / 5percent Pd/C / ethyl acetate / 18 h / 2585.7 Torr

4: aq. LiOH / tetrahydrofuran; methanol / 18 h / Ambient temperature

With lithium hydroxide; sodium tetrahydroborate; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm00055a011