(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-4-methyl-N-(3,3-dimethylbutyl)pentanamide lithium

Base Information

Chemical Name:(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-4-methyl-N-(3,3-dimethylbutyl)pentanamide lithium
CAS No.:1583283-25-3
Molecular Formula:C₂₁H₃₅N₃O₅P*Li
Molecular Weight:447.441
Hs Code.:

Synonyms:(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-4-methyl-N-(3,3-dimethylbutyl)pentanamide lithium

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Chemical Property of (S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-4-methyl-N-(3,3-dimethylbutyl)pentanamide lithium

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Technology Process of (S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-4-methyl-N-(3,3-dimethylbutyl)pentanamide lithium

There total 10 articles about (S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-4-methyl-N-(3,3-dimethylbutyl)pentanamide lithium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1583283-71-9
C₂₂H₃₈N₃O₅P

: 1583283-25-3
(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-4-methyl-N-(3,3-dimethylbutyl)pentanamide lithium

Guidance literature:: With lithium hydroxide; In water; acetonitrile;
DOI:10.1021/jm401609a

Reference yield:

: 621-84-1
O-benzyl carbamate

: 1583283-25-3
(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-4-methyl-N-(3,3-dimethylbutyl)pentanamide lithium

Guidance literature:: Multi-step reaction with 6 steps

1: sodium carbonate; water / water / 20 °C

2: pyridine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3: 3 h / Reflux

4: sodium hydroxide / 2 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 20 °C

6: lithium hydroxide / water; acetonitrile

With pyridine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; sodium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/jm401609a

Reference yield:

: 31037-42-0
hydroxymethyl carbamic acid benzyl ester

: 1583283-25-3
(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-4-methyl-N-(3,3-dimethylbutyl)pentanamide lithium

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2: 3 h / Reflux

3: sodium hydroxide / 2 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 20 °C

5: lithium hydroxide / water; acetonitrile

With pyridine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/jm401609a