tetraethyl 2-[5'-(4'-oxo-4'H-2-thioxo)-2'H-1',3'-thiazole]-2-phenylethylidine-1,1-bisphosphonate

Base Information

• Chemical Name: tetraethyl 2-[5'-(4'-oxo-4'H-2-thioxo)-2'H-1',3'-thiazole]-2-phenylethylidine-1,1-bisphosphonate
• CAS No.: 634915-40-5
• Molecular Formula: C₁₉H₂₉NO₇P₂S₂
• Molecular Weight: 509.521
• Mol file: 634915-40-5.mol

Synonyms:tetraethyl 2-[5'-(4'-oxo-4'H-2-thioxo)-2'H-1',3'-thiazole]-2-phenylethylidine-1,1-bisphosphonate

Chemical Property of tetraethyl 2-[5'-(4'-oxo-4'H-2-thioxo)-2'H-1',3'-thiazole]-2-phenylethylidine-1,1-bisphosphonate

Chemical Property:

Purity/Quality:

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Technology Process of tetraethyl 2-[5'-(4'-oxo-4'H-2-thioxo)-2'H-1',3'-thiazole]-2-phenylethylidine-1,1-bisphosphonate

There total 2 articles about tetraethyl 2-[5'-(4'-oxo-4'H-2-thioxo)-2'H-1',3'-thiazole]-2-phenylethylidine-1,1-bisphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

5-benzylidene-2-thioxothiazolidin-4-one (3806-42-6,174813-24-2) + Tetraethyl methylenediphosphonate (1660-94-2) → tetraethyl 2-[5'-(4'-oxo-4'H-2-thioxo)-2'H-1',3'-thiazole]-2-phenylethylidine-1,1-bisphosphonate (634915-40-5)

Guidance literature:

With sodium ethanolate; In ethanol; N,N-dimethyl-formamide; for 0.166667h; microwave irradiation;

DOI:10.1016/j.ejmech.2007.07.005

Reference yield: 48.0%

5-benzylidene-2-thioxothiazolidin-4-one (3806-42-6,174813-24-2) + Tetraethyl methylenediphosphonate (1660-94-2) → {4-Oxo-5-[1-phenyl-meth-(Z)-ylidene]-4,5-dihydro-thiazol-2-ylmethyl}-phosphonic acid diethyl ester + tetraethyl 2-[5'-(4'-oxo-4'H-2-thioxo)-2'H-1',3'-thiazole]-2-phenylethylidine-1,1-bisphosphonate (634915-40-5)

Guidance literature:

Tetraethyl methylenediphosphonate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

5-benzylidene-2-thioxothiazolidin-4-one; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 82.0%

tetraethyl 2-[5'-(4'-oxo-4'H-2-thioxo)-2'H-1',3'-thiazole]-2-phenylethylidine-1,1-bisphosphonate (634915-40-5) → 2-[5'-(4'-oxo-4'H-2-thioxo-2'H-1',3'-thiazole)]-2-phenylethylidene-1,1-bis-phosphonic acid

Guidance literature:

With hydrogenchloride; at 22 ℃; Heating;

upstream raw materials:

5-benzylidene-2-thioxothiazolidin-4-one

Tetraethyl methylenediphosphonate